{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:24:21Z","timestamp":1790943861132,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Deutscher Akademischer Austauschdienst"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In traditional Chinese medicine a number of herbs are used to alleviate the symptoms of aging, among them the stems of <jats:italic>Cynomorium songaricum<\/jats:italic>, Cynomoriaceae. This study evaluated the protective effect of different extracts of <jats:italic>C. songaricum<\/jats:italic> on staurosporine\u2010induced apoptotic cell death in SK\u2010N\u2010SH neuroblastoma cells. Staurosporine (100 n<jats:sc>m<\/jats:sc>) reduced cell viability to about 55%. The ethyl acetate fraction of <jats:italic>C. songaricum<\/jats:italic> significantly attenuated staurosporine\u2010induced cell death at concentrations of 100 and 10 \u00b5g\/mL. On the other hand, the dichloromethane as well as water fractions showed no protective effects. In order to further analyse the protective mode of action, the superoxide anion scavenging activity of two extracts was evaluated in a xanthine\/xanthine oxidase system. In this system, the EtOAc extract showed a good scavenging activity (IC<jats:sub>50<\/jats:sub> value 2.9 \u00b5g\/mL) without inhibition of xanthine oxidase. In conclusion, the results prove the neuroprotective activity of <jats:italic>C. songaricum<\/jats:italic> extracts <jats:italic>in vitro<\/jats:italic>, thus supporting its traditional use. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2605","type":"journal-article","created":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T18:51:18Z","timestamp":1223578278000},"page":"257-261","source":"Crossref","is-referenced-by-count":14,"title":["Extracts of <i>Cynomorium songaricum<\/i> protect SK\u2010N\u2010SH human neuroblastoma cells against staurosporine\u2010induced apoptosis potentially through their radical scavenging activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Yi","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias 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