{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T06:40:21Z","timestamp":1697179221543},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T00:00:00Z","timestamp":1229990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the appetite regulation mechanism of low and high molecular weight yeast hydrolysate, neuropeptide Y (NPY) and tryptophan hydroxylase (TPH) expressions were analyzed in the brains on rats using immunohistochemical method; normal diet (control), 0.1 g\/kg (BY\u20101) or 1.0 g\/kg (BY\u20102) of yeast hydrolysate below 10 kDa, 0.1 g\/kg (AY\u20101) or 1.0 g\/kg (AY\u20102) of yeast hydrolysate of 10\u201330 kDa. Body weight gain was lower in the BY\u20102 (133.0 g) than in the control (150.1 g) (<jats:italic>p<\/jats:italic> &lt; 0.05). Triacylglyceride, total cholesterol, and LDL\u2010cholesterol levels were lower in the BY\u20102 as compared to control, BY\u20101 and AY\u20102 (<jats:italic>p<\/jats:italic> &lt; 0.05). NPY staining intensities at paraventricular nucleus (PVN) were lower in the BY groups (BY\u20101: 96.1, BY\u20102: 88.6) as compared to the control (105.6) and AY groups (AY\u20101: 110.5, AY\u20102: 114.1) (<jats:italic>p<\/jats:italic> &lt; 0.05). NPY expression at lateral hypothalamic area (LHA) was lower in the BY\u20102 (92.3) than in the control (98.9) (<jats:italic>p<\/jats:italic> &lt; 0.05). The BY groups (BY\u20101: 143.9, BY\u20102: 154.6) had higher TPH staining intensities at dorsal raphe (DR) than the AY\u20102 (115.9) (<jats:italic>p<\/jats:italic> &lt; 0.05). In conclusion, the results indicate that administering yeast hydrolysate of below 10 kDa to normal diet\u2010fed rats reduced body weight gain and serum lipids by altering NPY and TPH expressions. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2668","type":"journal-article","created":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T12:22:26Z","timestamp":1230034946000},"page":"619-623","source":"Crossref","is-referenced-by-count":7,"title":["Effects of yeast hydrolysate on neuropeptide Y (NPY) and tryptophan hydroxylase (TPH) immunoreactivity in rats"],"prefix":"10.1002","volume":"23","author":[{"given":"Eun Young","family":"Jung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duk Ho","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Joo","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Un\u2010Jae","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.5.R1399"},{"key":"e_1_2_1_3_1","first-page":"1765","article-title":"Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism","volume":"266","author":"Billington CJ","year":"1994","journal-title":"Am J Physiol"},{"key":"e_1_2_1_4_1","first-page":"5","article-title":"Evidence for the existence of monoamine\u2010containing neurons in the central nervous system. 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