{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:24:09Z","timestamp":1770434649501,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,1,27]],"date-time":"2009-01-27T00:00:00Z","timestamp":1233014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The dichloromethane extract of the roots and heartwood of <jats:italic>Caesalpinia sappan<\/jats:italic> exhibited potent inhibitory activity against <jats:italic>\u03b2<\/jats:italic>\u2010hexosaminidase release as marker of degranulation in rat basophilic leukemic (RBL\u20102H3) cells, with inhibition of 98.7% and 87.5% at concentration of 100 \u00b5g\/ml, respectively. These extracts were further separated by chromatographic techniques to give two chalcones and seven homoisoflavones. Among the compounds tested, sappanchalcone (2) possessed the most potent effect against allergic reaction in RBL\u20102H3 cells with an inhibitory concentration (IC<jats:sub>50<\/jats:sub>) value of 7.6 \u00b5M, followed by 3\u2010deoxysappanchalcone (1, IC<jats:sub>50<\/jats:sub> = 15.3 \u00b5M), whereas other compounds showed moderate and mild effects. The results suggested the following structural requirements of chalcones (1 and 2) and homoisoflavones (3\u20109) for anti\u2010allergic activity: (i) chalcone exhibited higher activity than homoisoflavone (ii) vicinal hydroxylation at B\u2010ring of chalcone conferred higher activity than one hydroxylation; and (iii) for homoisoflavone, the hydroxyl groups at C\u20103 and C\u20104 positions decreased the activity. This is the first report of <jats:italic>C. sappan<\/jats:italic> for anti\u2010allergic activity. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2670","type":"journal-article","created":{"date-parts":[[2009,1,27]],"date-time":"2009-01-27T09:49:41Z","timestamp":1233049781000},"page":"1028-1031","source":"Crossref","is-referenced-by-count":52,"title":["Anti\u2010allergic activity of principles from the roots and heartwood of <i>caesalpinia sappan<\/i> on antigen\u2010induced <i>\u03b2<\/i>\u2010hexosaminidase release"],"prefix":"10.1002","volume":"23","author":[{"given":"Orapun","family":"Yodsaoue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarot","family":"Cheenpracha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatchanok","family":"Karalai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanita","family":"Ponglimanont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supinya","family":"Tewtrakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.26.1534"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957394"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2006.09.031"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957520"},{"key":"e_1_2_1_6_1","first-page":"361","volume-title":"Immunology","author":"Goldsby RA","year":"2002"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01639-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.12.009"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.08.027"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.34.1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.35.3002"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)82298-0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.35.3568"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.35.2761"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957481"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.34.2506"},{"key":"e_1_2_1_17_1","first-page":"1002","article-title":"Regulation of homocytotropic antibody formulation in the rat. 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