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The present study was designed to determine the possible protective effect of grape seed extract (GSE), rich in proanthocyanidins against <jats:italic>\u03b3<\/jats:italic>\u2010radiation\u2010induced oxidative stress in heart and pancreas tissues associated with serum metabolic disturbances. Irradiated rats were whole body exposed to 5 Gy <jats:italic>\u03b3<\/jats:italic>\u2010radiation. GSE\u2010treated irradiated rats received 100 mg GSE\/kg\/day, by gavage, for 14 days before irradiation. The animals were killed on days 1, 14 and 28 after irradiation. Significant decreases of SOD, CAT and GSH\u2010Px activities associated with significant increases of TBARS levels were recorded in both tissues after irradiation. GSE administration pre\u2010irradiation significantly attenuated the radiation\u2010induced oxidative stress in heart tissues which was substantiated by a significant amelioration of serum LDH, CPK and AST activities. GSE treatment also attenuated the oxidative stress in pancreas tissues which was associated with a significant improvement in radiation\u2010induced hyperglycemia and hyperinsulinemia. In conclusion, the present data demonstrate that GSE would protect the heart and pancreas tissues from oxidative damage induced by ionizing irradiation. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2684","type":"journal-article","created":{"date-parts":[[2008,11,11]],"date-time":"2008-11-11T11:47:13Z","timestamp":1226404033000},"page":"434-438","source":"Crossref","is-referenced-by-count":40,"title":["Grape seed extract <i>Vitis vinifera<\/i> protects against radiation\u2010induced oxidative damage and metabolic disorders in rats"],"prefix":"10.1002","volume":"23","author":[{"given":"Helen N.","family":"Saada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ussama Z.","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nefissa H.","family":"Meky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afrag S. 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