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The present study was performed to assess the <jats:italic>in vitro<\/jats:italic> effects of usnic acid from <jats:italic>Usnea dasypoga<\/jats:italic> against clinical isolates and standard <jats:italic>H. pylori<\/jats:italic> strains and their minimum inhibitory concentrations (MICs). A total of 38 strains was assayed for anti\u2010<jats:italic>H. pylori<\/jats:italic> activity. The agar dilution method was used for the determination of usnic acid and clarithromycin resistance.<\/jats:p><jats:p>Six (16.2%) clinical isolates were resistant to usnic acid and five (13.5%) were resistant to clarithromycin. Dual susceptibility to usnic acid and clarithromycin rate was detected as very high (97.3%). Usnic acid has a strong and dose\u2010dependent activity against <jats:italic>H. pylori<\/jats:italic> strains. The synergism between usnic acid and clarithromycin may be effective in the treatment of <jats:italic>H. pylori<\/jats:italic> infection. 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