{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:42:29Z","timestamp":1777329749782,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,3,9]],"date-time":"2009-03-09T00:00:00Z","timestamp":1236556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Herbal drugs are often used in patients with somatoform disorders yet, the available evidence is limited. The aim of the present short\u2010term study was to evaluate in a pharmaco\u2010clinical trial the additional benefit of butterbur in a fixed herbal drug combination (Ze 185 = 4\u2010combination versus 3\u2010combination without butterbur and placebo) in patients with somatoform disorders.<\/jats:p><jats:p>For a 2\u2010week treatment in patients with somatization disorder (F45.0) and undifferentiated somatoform disorder (F45.1), 182 patients were randomized for a 3\u2010arm trial (butterbur root, valerian root, passionflower herb, lemon balm leaf versus valerian root, passionflower herb, lemon balm leaf versus placebo). Anxiety (visual analogue scale \u2013 VAS) and depression (Beck's Depression Inventory \u2013 BDI) served as primary parameters, Clinical Global Impression (CGI) was a secondary parameter.<\/jats:p><jats:p>The 4\u2010combination was significantly superior to the 3\u2010combination and placebo (4\u2010combination &gt; 3\u2010combination &gt; placebo) in all the primary and secondary parameters (PP\u2010population). Analysis of the ITT population confirmed these results. As to safety, no serious adverse events occurred. In total 9 non\u2010serious adverse events were documented but the distribution did not differ significantly between the treatment groups.<\/jats:p><jats:p>This herbal preparation (Ze185) showed to be an efficacious and safe short\u2010term treatment in patients with somatoform disorders. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2771","type":"journal-article","created":{"date-parts":[[2009,3,9]],"date-time":"2009-03-09T16:25:29Z","timestamp":1236615929000},"page":"1303-1308","source":"Crossref","is-referenced-by-count":15,"title":["Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo\u2010controlled pharmaco\u2010clinical trial"],"prefix":"10.1002","volume":"23","author":[{"given":"J\u00f6rg","family":"Melzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewald","family":"Schrader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Brattstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Schellenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Saller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2001.00367.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PSY.0000024231.11538.8F"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959492"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(03)00112-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.02.023"},{"key":"e_1_2_1_8_1","unstructured":"H Dilling W Mombour MH Schmidt 2005 Hans Huber Bern G\u00f6ttingen Toronto"},{"key":"e_1_2_1_9_1","unstructured":"European Scientific Cooperative on Phytotherapy (ESCOP) HESCOP 2003 Thieme Stuttgart New York"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1080\/j.1440-1614.2005.01682.x","article-title":"Classification of somatization and functional somatic symptoms in primary care","volume":"39","author":"Fink P","year":"2005","journal-title":"Aust N Z J Psychiatry"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/J157v05n03_12"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.44.4.304"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60159-7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540260500466766"},{"key":"e_1_2_1_15_1","first-page":"41","article-title":"The common butterbur (Petasites hybridus) \u2013 portrait of a medicinal herb","volume":"10","author":"K\u00e4lin P","year":"2003","journal-title":"Forsch Komplementarmed Klass Naturheilkd"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000132877.72833.71"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8620"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2004.04.372"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177730491"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(03)00121-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)01964-1"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000128900.13711.5b"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-14055"},{"key":"e_1_2_1_24_1","volume-title":"Clinical evaluation of psychotropic drugs: principles and guidelines","author":"Rickels K","year":"1994"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(99)00023-9"},{"key":"e_1_2_1_26_1","volume-title":"Kaplan & Sadock's synopsis of psychiatry. 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