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The expression of the GABA<jats:sub>A<\/jats:sub> receptor <jats:italic>\u03b1<\/jats:italic>\u2010subunit was increased selectively by magnolol, but magnolol had no effect on the abundance of <jats:italic>\u03b2<\/jats:italic>\u2010 or <jats:italic>\u03b3<\/jats:italic>\u2010subunits. The expression of glutamic acid decarboxylase (GAD) was not influenced by magnolol. It is suggested that magnolol may enhance pentobarbital\u2010induced sleeping behaviors through the activation of GABAergic systems. 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