{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:58:18Z","timestamp":1790985498245,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T00:00:00Z","timestamp":1236643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maesa saponins with the 13,28\u2010epoxy\u2010oleanane triterpene core skeleton were described recently to possess strong and selective<jats:italic> in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> antileishmania activity. In the absence of direct chemical derivatization possibilities, a structure\u2010based literature search was carried out to explore a structure\u2010activity relationship. Crude alcohol extracts from several plant species of Myrsinaceae, Primulaceae, Aceraceae and Icacinaceae were evaluated for <jats:italic>in vitro<\/jats:italic> activity against <jats:italic>Leishmania infantum<\/jats:italic> intracellular amastigotes and cytotoxicity on MRC\u20105<jats:sub>SV2<\/jats:sub> cells, while the saponin content was evaluated qualitatively by TLC. A clear correlation was found between the presence of close analogue 13,28\u2010epoxy\u2010oleanane triterpene saponins and potent and selective antileishmania activity. This was most striking in <jats:italic>Maesa species<\/jats:italic>, except for<jats:italic> M. macrosepala<\/jats:italic>. Interesting activities were also found in extracts that did not exactly match the TLC characteristics of the Maesa saponin references, as was the case for <jats:italic>Ardisia angusta<\/jats:italic>, <jats:italic>A. amherstiana<\/jats:italic>, <jats:italic>A. caudata<\/jats:italic>, <jats:italic>A. gigantifolia<\/jats:italic>, <jats:italic>A. roseiflora<\/jats:italic>, <jats:italic>Myrsine affinis<\/jats:italic>, <jats:italic>Acer brevipes<\/jats:italic> and <jats:italic>A. laurinum var. petelotii<\/jats:italic>. This study indicates that the 13,28\u2010epoxy\u2010oleanane triterpene moiety is essential for selective antileishmania potential and that several other plant species could still be explored for antileishmania drug discovery. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2788","type":"journal-article","created":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T10:03:05Z","timestamp":1236679385000},"page":"1404-1410","source":"Crossref","is-referenced-by-count":28,"title":["Selective antileishmania activity of 13,28\u2010epoxy\u2010oleanane and related triterpene saponins from the plant families Myrsinaceae, Primulaceae, Aceraceae and Icacinaceae"],"prefix":"10.1002","volume":"23","author":[{"given":"Marieke","family":"Vermeersch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenn","family":"Foubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Inoc\u00eancio da","family":"Luz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc Van","family":"Puyvelde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Pieters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,10]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(87)90084-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16489"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(99)00352-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50112a004"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.04.003"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.1.111-126.2006"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8541"},{"key":"e_1_2_1_9_1","first-page":"851","article-title":"Bioassay\u2010guided isolation of saponins from Apodytes dimidiata","volume":"73","author":"Foubert K","year":"2007","journal-title":"Planta Med"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/138527208784577376"},{"key":"e_1_2_1_11_1","unstructured":"FoubertK VermeerschM TheunisMet al.In press. 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