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In this study, two lignan constituents were isolated from<jats:italic>Saururus chinensis<\/jats:italic>Baill (Saururaceae) as inhibitors of cellular melanin production by bioassay\u2010guided fractionations. The active constituents were manassantin A and B that dose\u2010dependently inhibited melanin production in<jats:italic>\u03b1<\/jats:italic>\u2010melanocyte stimulating hormone (<jats:italic>\u03b1<\/jats:italic>\u2010MSH)\u2010activated melanoma B16 cells with IC<jats:sub>50<\/jats:sub>values of 13 n<jats:sc>m<\/jats:sc>and 8 n<jats:sc>m<\/jats:sc>, respectively. Arbutin as a positive control exhibited an IC<jats:sub>50<\/jats:sub>value of 96 \u00b5<jats:sc>m<\/jats:sc>on<jats:italic>\u03b1<\/jats:italic>\u2010MSH\u2010induced melanin production. Further, manassantin A inhibited forskolin\u2010 or 3\u2010isobutyl\u20101\u2010methylxanthine (IBMX)\u2010induced melanin production with IC<jats:sub>50<\/jats:sub>values of 14 n<jats:sc>m<\/jats:sc>or 12 n<jats:sc>m<\/jats:sc>, respectively. Manassantin A decreased cellular amounts of IBMX\u2010inducible tyrosinase protein but could not affect the catalytic activity of cell\u2010free tyrosinase, a key enzyme in the biosynthetic pathway of melanin pigments. Finally, this study could provide a pharmacological potential of<jats:italic>S. chinensis<\/jats:italic>in hyperpigmentation disorders. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2791","type":"journal-article","created":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T08:27:00Z","timestamp":1239784020000},"page":"1531-1536","source":"Crossref","is-referenced-by-count":26,"title":["Manassantin A and B from<i>Saururus chinensis<\/i>inhibiting cellular melanin production"],"prefix":"10.1002","volume":"23","author":[{"given":"Chang\u2010Seob","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won\u2010Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Wook","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ju","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung 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