{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:30:40Z","timestamp":1787679040808,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,3,13]],"date-time":"2009-03-13T00:00:00Z","timestamp":1236902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cryptolepine is the major alkaloid of the West African shrub, <jats:italic>Cryptolepis sanguinolenta<\/jats:italic>. Cryptolepine has been shown to inhibit nitric oxide production, and DNA binding of Nuclear Factor\u2010kappa B following inflammatory stimuli <jats:italic>in vitro<\/jats:italic>. In order to validate the anti\u2010inflammatory property of this compound <jats:italic>in vivo<\/jats:italic>, we investigated its effects on a number of animal models of inflammation. Cryptolepine (10\u201340 mg\/kg i.p.) produced significant dose\u2010dependent inhibition of the carrageenan\u2010induced rat paw oedema, and carrageenan\u2010induced pleurisy in rats. These effects were compared with those of the non\u2010steroidal anti\u2010inflammatory drug indomethacin (10 mg\/kg). At doses of 10\u201340 mg\/kg i.p., cryptolepine inhibited lipopolysaccharide (LPS)\u2010induced microvascular permeability in mice in a dose\u2010related fashion. Oral administration of up to 40 mg\/kg of the compound for four consecutive days did not induce gastric lesion formation in rats. Analgesic activity was also exhibited by cryptolepine through a dose\u2010related (10\u201340 mg\/kg i.p.) inhibition of writhing induced by i.p. administration of acetic acid in mice. The results of this study reveal that cryptolepine possesses <jats:italic>in vivo<\/jats:italic> anti\u2010inflammatory activity. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2794","type":"journal-article","created":{"date-parts":[[2009,3,14]],"date-time":"2009-03-14T00:21:14Z","timestamp":1236990074000},"page":"1421-1425","source":"Crossref","is-referenced-by-count":59,"title":["Anti\u2010inflammatory properties of cryptolepine"],"prefix":"10.1002","volume":"23","author":[{"given":"Olumayokun A.","family":"Olajide","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abayomi M.","family":"Ajayi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin W.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,13]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"130","article-title":"Some aspects of the pharmacology of butifen, a non steroidal anti \u2013 inflammatory 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