{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:57:15Z","timestamp":1790477835422,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T00:00:00Z","timestamp":1239753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Food & Drug Administration, Republic of Korea; Korea Research Foundation Grant funded by the Korean Government","award":["MOEHRD"],"award-info":[{"award-number":["MOEHRD"]}]},{"name":"Food & Drug Administration, Republic of Korea; Korea Research Foundation Grant funded by the Korean Government","award":["KRF-2008-005-J00601"],"award-info":[{"award-number":["KRF-2008-005-J00601"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of <jats:italic>Poncirus trifoliata<\/jats:italic> (<jats:italic>P. trifoliata<\/jats:italic>) (<jats:italic>Ponciri Fructus<\/jats:italic>, PF) extract and its constituents such as neohesperidin and poncirin on gastritis in rats and human gastric cancer cells were investigated. The PF 70% ethanol extracts (1 g) showed approximately 11.38% of acid\u2010neutralizing capacities and cytotoxicity (IC<jats:sub>50<\/jats:sub> = 85.39 \u00b5g\/mL) against human AGS gastric cancer cells. In addition, neohesperidin exhibited antioxidant activity (IC<jats:sub>50<\/jats:sub> = 22.31 \u00b5g\/mL) in the 1,1\u2010diphenyl\u20102\u2010picryldydrazyl (DPPH) radical\u2010scavenging assay. Neohesperidin (50 mg\/kg) and poncirin (100 mg\/kg) significantly inhibited 55.0% and 60.0% of HCl\/ethanol\u2010induced gastric lesions, respectively, and increased the mucus content. In pylorus ligated rats, neohesperidin (50 mg\/kg) significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH. From these results, it could be suggested that neohesperidin and poncirin isolated from PF may be useful for the treatment and\/or protection of gastritis. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2840","type":"journal-article","created":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T08:45:38Z","timestamp":1239785138000},"page":"1748-1753","source":"Crossref","is-referenced-by-count":77,"title":["Protective effects of neohesperidin and poncirin isolated from the fruits of <i>Poncirus trifoliata<\/i> on potential gastric disease"],"prefix":"10.1002","volume":"23","author":[{"given":"Je\u2010Hyuk","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Shik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon 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