{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:17:05Z","timestamp":1790522225721,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T00:00:00Z","timestamp":1245628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"crossref","award":["K2007-03X-007904-20A"],"award-info":[{"award-number":["K2007-03X-007904-20A"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"crossref"}]},{"name":"F\u00e4rs and Frosta Foundation (Sparbankstiftelsen); Dr P. H\u00e5kanson Foundation; Ferrosan AB"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thylakoids are membranes isolated from plant chloroplasts which have previously been shown to inhibit pancreatic lipase\/colipase catalysed hydrolysis of fat <jats:italic>in vitro<\/jats:italic> and induce short\u2010term satiety <jats:italic>in vivo<\/jats:italic>. The purpose of the present study was to examine if dietary supplementation of thylakoids could affect food intake and body weight during long\u2010term feeding in mice. Female apolipoprotein E\u2010deficient mice were fed a high\u2010fat diet containing 41% of fat by energy with and without thylakoids for 100 days. Mice fed the thylakoid\u2010enriched diet had suppressed food intake, body weight gain and body fat compared with the high\u2010fat fed control mice. Reduced serum glucose, serum triglyceride and serum free fatty acid levels were found in the thylakoid\u2010treated animals. The satiety hormone cholecystokinin was elevated, suggesting this hormone mediates satiety. Leptin levels were reduced, reflecting a decreased fat mass. There was no sign of desensitization in the animals treated with thylakoids. The results suggest that thylakoids are useful to suppress appetite and body weight gain when supplemented to a high\u2010fat food during long\u2010term feeding. 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