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(Theaceae) (CS) was assayed for its potential to inhibit enzymes with hydrolytic activity in <jats:italic>Naja naja kaouthia<\/jats:italic> Lesson (Elapidae) and <jats:italic>Calloselasma rhodostoma<\/jats:italic> Kuhl (Viperidae) venoms. These snake venom enzymes are responsible for the early effects of envenomation, such as local tissue damage and inflammation. The CS extract inhibited phospholipase A<jats:sub>2<\/jats:sub>, proteases, hyaluronidase and l\u2010amino acid oxidase in both venoms by <jats:italic>in vitro<\/jats:italic> neutralization and inhibited the hemorrhagic and the dermonecrotic activities of the venoms <jats:italic>in vivo<\/jats:italic>. It is suggested that the inhibitory potential of the CS extract against local tissue damage induced by snake venoms may be attributed to complexation and chelation between the venom proteins and the phenolic contents of the extract. 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