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All subjects were divided into two groups to receive purslane (<jats:italic>n<\/jats:italic> = 20) or placebo (<jats:italic>n<\/jats:italic> = 17) for 3 months. Assessments were made at baseline, after 2 weeks and each month for 6 months, based on the visual analog scale (VAS) and clinical improvement including lesion type and size. Approximately 83% of the purslane patients showed partial to complete clinical improvement but 17% had no response. In the placebo group 17% experienced partial improvement, 73% did not respond and 10% showed worsening. According to VAS scores, a partial to complete response was observed in all purslane\u2010treated patients, while 71%, 15% and 14% of the controls demonstrated partial response, no response and worsening of the symptoms, respectively. A significant decrease in VAS scores was seen at the end of the study period (<jats:italic>p<\/jats:italic> &lt; 0.001). No serious side\u2010effects occurred in either of the groups. According to our findings purslane is clinically effective in the treatment of OLP. Considering the lack of side\u2010effects during the study period, it may be a favorable alternative treatment for OLP. 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