{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:21:38Z","timestamp":1773080498177,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T00:00:00Z","timestamp":1255392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Rosmarinus officinalis<\/jats:italic> (Lamiaceae) possesses antioxidant activity and hepatoprotective effects, and so may provide a possible therapeutic alternative for chronic liver disease. The effect produced by a methanolic extract of <jats:italic>Rosmarinus officinalis<\/jats:italic> on CCl<jats:sub>4<\/jats:sub>\u2010induced liver cirrhosis in rats was investigated using both prevention and reversion models. Over the course of the development of cirrhosis, the increased enzymatic activities of gamma\u2010glutamyl transpeptidase and alanine aminotransferase, and the rise in bilirubin levels caused by CCl<jats:sub>4<\/jats:sub> administration, were prevented by <jats:italic>Rosmarinus officinalis<\/jats:italic> co\u2010administration. When the cirrhosis by oxidative stress was evaluated as an increase on liver lipoperoxidation, total lipid peroxides, nitric oxide in serum, and loss of erythrocyte plasma membrane stability, <jats:italic>R. officinalis<\/jats:italic> was shown to prevent such alterations. On cirrhotic animals treated with CCl<jats:sub>4<\/jats:sub>, histological studies showed massive necrosis, periportal inflammation and fibrosis which were modified by <jats:italic>R. officinalis<\/jats:italic>. These benefits on experimental cirrhosis suggest a potential therapeutic use for <jats:italic>R. officinalis<\/jats:italic> as an alternative for liver cirrhosis. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2997","type":"journal-article","created":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T22:14:35Z","timestamp":1255472075000},"page":"595-601","source":"Crossref","is-referenced-by-count":42,"title":["Oxidative stress modulation by <i>Rosmarinus officinalis<\/i> in CCl<sub>4<\/sub>\u2010induced liver cirrhosis"],"prefix":"10.1002","volume":"24","author":[{"given":"Rosalinda","family":"Guti\u00e9rrez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 L.","family":"Alvarado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Presno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"P\u00e9rez\u2010Veyna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen J.","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Yahuaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,13]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.09.048"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498259209046624"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2006.10.009"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0715323"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563659309000383"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1186"},{"key":"e_1_2_1_8_1","unstructured":"CrawfordJM.2000.El h\u00edgado y las v\u00edas biliares. 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