{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:02:45Z","timestamp":1789801365954,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T00:00:00Z","timestamp":1255392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Malassezia furfur<\/jats:italic> is a lipodependent, dimorphic and saprophyte fungus which causes pityriasis versicolor, dandruff and seborrheic dermatitis in humans. The drugs available to treat this fungal infection are few. These drugs are highly toxic and are costly when used in prolonged treatments. For these reasons, it is necessary to find new compounds to treat these infections. <jats:italic>Ilex paraguariensis<\/jats:italic> St Hilaire is a plant that grows in Argentina, Brazil and Paraguay. The aim of this study was to evaluate the effect of the aqueous extract of <jats:italic>Ilex paraguariensis<\/jats:italic> on the growth of <jats:italic>M. furfur<\/jats:italic>. High performance liquid chromatography (HPLC) was employed to identify and isolate compounds of <jats:italic>I. paraguariensis<\/jats:italic> and the agar\u2010well diffusion method was used to assess the antifungal activity of the extract. The fungicidal\/fungistatic effect was evaluated by the modified Thompson assay. The results demonstrated that the aqueous extract of <jats:italic>Ilex paraguariensis<\/jats:italic> (1000\u2009mg\/ml) possesses inhibitory activity against <jats:italic>M. furfur<\/jats:italic>. This anti<jats:italic>malassezial<\/jats:italic> activity was equivalent to 2.7\u2009\u03bcg\/ml of ketoconazole. Therefore, the topical use of <jats:italic>Ilex paraguariensis<\/jats:italic> extract as alternative antifungal agent can be suggested. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3004","type":"journal-article","created":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T22:07:42Z","timestamp":1255471662000},"page":"715-719","source":"Crossref","is-referenced-by-count":48,"title":["Antifungal activity of the aqueous extract of <i>Ilex paraguariensis<\/i> against <i>Malassezia furfur<\/i>"],"prefix":"10.1002","volume":"24","author":[{"given":"Rosana","family":"Filip","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Davicino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Anesini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,13]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2006.05.013"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.05.025"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(93)90027-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-58062-8"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19921040906"},{"key":"e_1_2_1_7_1","volume-title":"Pharmacognosy, phytochemistry of medicinal plants","author":"Bruneton J","year":"1995"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007132830164"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/87559128709540808"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.15381\/rpb.v14i2.1784","article-title":"Antifungal activity of plant extracts used in folk medicine in Argentina","volume":"14","author":"Davicino R","year":"2007","journal-title":"Rev Peru Biol"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01508.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.2340\/0001555570171172","article-title":"Treatment of seborrhoeic dermatitis of the scalp with ketoconazole shampoo. 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