{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:23:35Z","timestamp":1791995015418,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T00:00:00Z","timestamp":1259712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of the present study was to evaluate <jats:italic>in vitro<\/jats:italic> antitrypanosomal and cytotoxic activities of crude extracts of 20 traditionally used medicinal plants of Tanzania. A total of 40 extracts (dichloromethane and methanol) were screened for antiproliferative activity of bloodstream form of <jats:italic>T<\/jats:italic>. <jats:italic>b<\/jats:italic>. <jats:italic>brucei<\/jats:italic> and human leukaemia HL\u201060 cell. Inhibition of cell proliferation was assessed using resazurin as vital stain. Of the 40 extracts tested, the dichloromethane extract from bark of <jats:italic>Warburgia salutaris<\/jats:italic> (Canellaceae) exhibited the most potent antitrypanosomal activity with an IC<jats:sub>50<\/jats:sub> value of 10.68\u2009\u03bcg\/ml. A dichloromethane extract from <jats:italic>Lannea stuhlmannii<\/jats:italic> (Anacardiaceae) was found to be the most cytotoxic extract against HL\u201060 (IC<jats:sub>50<\/jats:sub> = 27.15\u2009\u03bcg\/ml). Out of the 20 plants tested, 5 plants exhibited trypanocidal activity with IC<jats:sub>50<\/jats:sub> values below 20\u2009\u03bcg\/ml. These 5 plants: <jats:italic>Entandrophragma bussei<\/jats:italic> (Meliaceae), <jats:italic>Securidaca longepedunculata<\/jats:italic> (Polygalaceae), <jats:italic>Warburgia salutaris<\/jats:italic> (Canellaceae), <jats:italic>Zanha africana<\/jats:italic> (Sapindaceae) and <jats:italic>Zanthoxylum chalybeum<\/jats:italic> (Rutaceae) could therefore serve as sources of lead compounds for treatment of trypanosomiasis. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3066","type":"journal-article","created":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T14:14:31Z","timestamp":1259763271000},"page":"945-947","source":"Crossref","is-referenced-by-count":52,"title":["Screening of some Tanzanian medicinal plants for their trypanocidal and cytotoxic activities"],"prefix":"10.1002","volume":"24","author":[{"given":"Endalkachew","family":"Nibret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed L.","family":"Ashour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrispinus D.","family":"Rubanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03772.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(84)90037-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(90)90041-Q"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(02)00237-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(97)00064-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0001-706X(93)90083-N"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-006-0126-y"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.02.008"},{"key":"e_1_2_1_10_1","volume-title":"Medicinal plants of the world","author":"van Wyk B\u2010E","year":"2004"},{"key":"e_1_2_1_11_1","volume-title":"WHO traditional medicine strategy 2002\u20132005","author":"WHO","year":"2002"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.3066","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.3066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.3066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T13:58:08Z","timestamp":1700575088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.3066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,26]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1002\/ptr.3066"],"URL":"https:\/\/doi.org\/10.1002\/ptr.3066","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,26]]}}}