{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:40:15Z","timestamp":1791070815952,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2009,12,29]],"date-time":"2009-12-29T00:00:00Z","timestamp":1262044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The effects of aqueous\u2010methanol extract of\n                    <jats:italic>Saussurea lappa Clarke<\/jats:italic>\n                    root (Sl.Cr) was investigated against D\u2010galactosamine (D\u2010GalN) and lipopolysaccharide (LPS)\u2010induced hepatitis in mice. Co\u2010administration of D\u2010GalN (700 mg\/kg) and LPS (1 \u03bcg\/kg) significantly raised the plasma transaminase levels (ALT\/AST) as compared to the control group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Pretreatment of mice with different doses of Sl.Cr (150, 300 and 600 mg\/kg) significantly prevented the D\u2010GalN and LPS\u2010induced rise in plasma levels of ALT and AST in a dose\u2010dependent manner (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Post\u2010treatment with Sl.Cr (600 mg\/kg) significantly restricted the progression of hepatic damage induced by D\u2010GalN and LPS (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). The improvement in plasma enzyme levels was further verified by histopathology of the liver, which showed improved architecture, absence of parenchyma congestion, decreased cellular swelling and apoptotic cells in treatment groups as compared to the toxin group of animals. These data indicate that the Sl.Cr exhibits hepatoprotective effect in mice and this study rationalize the traditional use of this plant in liver disorders. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/ptr.3089","type":"journal-article","created":{"date-parts":[[2009,12,29]],"date-time":"2009-12-29T04:19:55Z","timestamp":1262060395000},"source":"Crossref","is-referenced-by-count":54,"title":["Antihepatotoxic activity of\n                    <i>Saussurea lappa<\/i>\n                    extract on D\u2010galactosamine and lipopolysaccharide\u2010induced hepatitis in mice"],"prefix":"10.1002","volume":"24","author":[{"given":"Sheikh","family":"Yaeesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qamar","family":"Jamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Jabbar","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwarul Hassan","family":"Gilani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(94)00083-K"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957528"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.33549\/physiolres.930000.49.261","article-title":"Evaluation of calcium channel blockers as potential hepatoprotective agents in oxidative stress injury of perfused hepatocytes","volume":"49","author":"Farghali H","year":"2000","journal-title":"Physiol Res"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2098"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840120518"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"R1196","DOI":"10.1152\/ajpregu.2000.278.5.R1196","article-title":"Lipopolysaccharide and D\u2010galactosamine\u2010induced hepatic injury is mediated by TNF\u2010\u03b1 and not by FAS ligand","volume":"278","author":"Joseph MD","year":"2000","journal-title":"Am J Physiol \u2013 Regul Integ Compar Physiol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-13968"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(02)00471-6"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292706"},{"key":"e_1_2_1_11_1","first-page":"1036","volume-title":"Indian Materia Medica","author":"Nadkarni KM.","year":"1976"},{"key":"e_1_2_1_12_1","first-page":"1","volume-title":"Guide for the care and use of laboratory animals","author":"Natonal Research Councl (NRC)","year":"1996"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/28.1.56"},{"key":"e_1_2_1_14_1","first-page":"100","volume-title":"Diseases of the liver; Greco\u2010Arabic concepts","author":"Said HM.","year":"1982"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(89)90208-6"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.3089","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.3089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.3089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T06:56:10Z","timestamp":1739688970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.3089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":14,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1002\/ptr.3089"],"URL":"https:\/\/doi.org\/10.1002\/ptr.3089","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}