{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:48:05Z","timestamp":1791118085256,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T00:00:00Z","timestamp":1261008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute subcutaneous administration of Angiotensin II (Ang II) causes a rise in blood pressure in diabetic Wistar rats. Diabetes was induced using streptozotocin (70\u2009mg\/kg, i.v.). Chronic administration of pomegranate juice (PJ) extract (100\u2009mg\/kg and 300\u2009mg\/kg; p.o. for 4 weeks) obtained from <jats:italic>Punica granatum<\/jats:italic> (punicaceae) fruits reduced the mean arterial blood pressure and vascular reactivity changes to various catecholamines and also reversed the biochemical changes induced by diabetes and Ang II. PJ treatment also caused a significant decrease in levels of thiobarbituric acid reactive substances (TBARS) in kidney and pancreas while activities of enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSH) showed significant elevation. The cumulative concentration response curve (CCRC) of Ang II was shifted towards right in rats treated with PJ using isolated strip of ascending colon. In histopathological examination, PJ treatment prevented the tubular degenerative changes induced by diabetes. The results suggest that the PJ extract could prevent the development of high blood pressure induced by Ang II in diabetic rats probably by combating the oxidative stress induced by diabetes and Ang II and by inhibiting ACE activity. In conclusion, PJ has antihypertensive action in Ang II diabetic model. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3090","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T20:22:22Z","timestamp":1261081342000},"source":"Crossref","is-referenced-by-count":57,"title":["Effect of pomegranate juice on Angiotensin II\u2010induced hypertension in diabetic wistar rats"],"prefix":"10.1002","volume":"24","author":[{"given":"Mahalaxmi","family":"Mohan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshal","family":"Waghulde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kasture","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"F477","DOI":"10.1152\/ajprenal.1993.265.4.F477","article-title":"Renal renin\u2010angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations","volume":"265","author":"Anderson S","year":"1993","journal-title":"Am J Physiol Renal Fluid Electrolyte Physiol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00412-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","article-title":"A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase","volume":"115","author":"Beers RF","year":"1952","journal-title":"J Biological Chem"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00017.2006"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(71)90292-9"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.740"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf000404a"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq1201.098769"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2007.07.002"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00170-1"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00237.x"},{"key":"e_1_2_1_15_1","first-page":"301","volume-title":"Clinical Chemistry; Interpretation and Techniques","author":"Kaplan A","year":"1983"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)90143-0"},{"key":"e_1_2_1_17_1","first-page":"107","volume-title":"Practical Pharmacognosy","author":"Kokate CK.","year":"1994"},{"key":"e_1_2_1_18_1","first-page":"1268","volume-title":"Clinical Chemistry: Theory Analysis and Co\u2010relation","author":"Koller A.","year":"1984"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2008.01.003"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2005.08.012"},{"key":"e_1_2_1_21_1","first-page":"131","article-title":"Mechanism of action of ACE\u2010inhibitors and angiotensin receptor antagonists in diabetic nephropathy","volume":"94","author":"Martinelli L","year":"2003","journal-title":"Recent Prog Med"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1016\/S0021-9258(19)44679-6","article-title":"The generation Superoxide radical during the autooxidation of hemoglobin","volume":"247","author":"Misra HP","year":"1972","journal-title":"J Bio Chem"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-007-0007-6"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01231077"},{"key":"e_1_2_1_25_1","volume-title":"National Diabetes Data group (ad): Diabetes in America","author":"National Diabetes Data Group","year":"1985"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102619"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1968.tb00428.x"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2007.04.005"},{"key":"e_1_2_1_29_1","first-page":"59","article-title":"Effect of an alcoholic extract from the epicarp of roma (Punica granatum L.) on insulin hypoglycaemia","volume":"67","author":"Nogueira DG","year":"1986","journal-title":"Rev Bras Farm"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00491.2002"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1964.tb01591.x"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2006.01.008"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.09.006"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb11759.x"},{"key":"e_1_2_1_35_1","first-page":"551","article-title":"Renal hypertrophy in streptozotocin\u2010dia betic rats","volume":"51","author":"Seyer\u2010Hansen K.","year":"1976","journal-title":"Clin Sci Mol Med"},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5344\/ajev.1977.28.1.49","article-title":"Total phenol analyses: Automation and comparison with manual methods","volume":"28","author":"Slinkard K","year":"1977","journal-title":"Am J Enol Viticul"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1997.0154"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2004.11.002"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02230-0"},{"key":"e_1_2_1_40_1","first-page":"99","article-title":"Analysis of propolis: some parameters and procedures for chemical quality control","volume":"37","author":"Woisky RG","year":"1998","journal-title":"J Agri Res"},{"key":"e_1_2_1_41_1","first-page":"3","article-title":"Antidiabetic activity of Punica granatum Linn","volume":"56","author":"Zafar R","year":"1990","journal-title":"Sci Cult"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.3090","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.3090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T07:14:39Z","timestamp":1694502879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.3090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":40,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1002\/ptr.3090"],"URL":"https:\/\/doi.org\/10.1002\/ptr.3090","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}