{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:05:52Z","timestamp":1773144352462,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,2,4]],"date-time":"2010-02-04T00:00:00Z","timestamp":1265241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antibiotic resistance is increasing resulting in a decreasing number of fully active antimicrobial agents available to treat infections with multi\u2010drug resistant (MDR) bacteria. Herbal medicines may offer alternative treatment options. A direct inoculation method simulating the standard disc diffusion assay was developed to determine <jats:italic>in vitro<\/jats:italic> antimicrobial activity of sixty herbal extracts against MDR\u2010<jats:italic>Acinetobacter baumannii<\/jats:italic> (<jats:italic>A. baumannii<\/jats:italic>). Eighteen herbal extracts inhibited MDR\u2010<jats:italic>A. baumannii<\/jats:italic> on agar plates, although the magnitude and quality of bacterial inhibition differed considerably among the antibacterial herbal extracts. Next, minimal inhibitory concentration (MIC) of these antibacterial herbal extracts was calculated using a broth microdilution assay. For most herbal extracts, the larger the zone of inhibition on agar plates, the lower the MIC. In general, hetero\u2010resistance on agar plates correlated with higher MIC. The skip well phenomenon was seen with two herbal extracts. In conclusion, 30% of the screened herbal extracts demonstrated <jats:italic>in vitro<\/jats:italic> antibacterial activity against MDR\u2010<jats:italic>A. baumannii<\/jats:italic> using similar rigorous testing methods as those commonly employed for assessing antimicrobial activity of synthetic antibacterial agents. Characterization of a specific compound conferring this antibacterial activity of the herbal extracts may help to identify novel antimicrobial agents active against highly resistant bacteria. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3113","type":"journal-article","created":{"date-parts":[[2010,2,4]],"date-time":"2010-02-04T10:57:34Z","timestamp":1265281054000},"page":"1202-1206","source":"Crossref","is-referenced-by-count":21,"title":["Screening of herbal extracts against multi\u2010drug resistant <i>Acinetobacter baumannii<\/i>"],"prefix":"10.1002","volume":"24","author":[{"given":"Yoko","family":"Miyasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Stephen","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margie A.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie A.","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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