{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T14:51:11Z","timestamp":1772031071758,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T00:00:00Z","timestamp":1274054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The protective effects of common dandelion leaf water extract (DLWE) were investigated by carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) induced hepatitis in Sprague\u2010Dawley rats. The animals were divided into five groups: normal control, DLWE control, CCl<jats:sub>4<\/jats:sub> control, and two DLWE groups (0.5 and 2\u2009g\/kg bw). After 1 week of administering corresponding vehicle or DLWE, a single dose of CCl<jats:sub>4<\/jats:sub> (50% CCl<jats:sub>4<\/jats:sub>\/olive oil; 0.5\u2009mL\/kg bw) was administered 24\u2009h before killing in order to produce acute liver injury. The DLWE treatment significantly decreased CCl<jats:sub>4<\/jats:sub>\u2010induced hepatic enzyme activities (AST, ALT and LDH) in a dose dependent manner. Also, the obstructed release of TG and cholesterol into the serum was repaired by DLWE administration. Hepatic lipid peroxidation was elevated while the GSH content and antioxidative enzyme activities were reduced in the liver as a result of CCl<jats:sub>4<\/jats:sub> administration, which were counteracted by DLWE administration. Furthermore, the hepatocytotoxic effects of CCl<jats:sub>4<\/jats:sub> were confirmed by significantly elevated Fas and TNF\u2010? mRNA expression levels, but DLWE down\u2010regulated these expressions to the levels of the normal control. Highly up\u2010regulated cytochrome P450 2E1 was also lowered significantly in the DLWE groups. These results indicate that DLWE has a protective effect against CCl<jats:sub>4<\/jats:sub>\u2010induced hepatic damage with at least part of its effect being attributable to the attenuation of oxidative stress and inflammatory processes resulting from cytochrome P450 activation by CCl<jats:sub>4<\/jats:sub>. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3121","type":"journal-article","created":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T15:46:19Z","timestamp":1274111179000},"page":"1347-1353","source":"Crossref","is-referenced-by-count":48,"title":["Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in sprague\u2010dawley rats"],"prefix":"10.1002","volume":"24","author":[{"given":"Chung Mu","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon Suk","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Joo","family":"Youn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Won","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Sun","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,25]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(02)00032-2"},{"key":"e_1_2_1_3_1","first-page":"14","volume-title":"Methods of Enzymatic Analysis","author":"Bergmeyer HU","year":"1983"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00762-8"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/152308602760598909"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.011585"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.09.054"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1556\/AAlim.29.2000.1.1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0258858"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000044364.73144.fe"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.03.009"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.3.1020S"},{"key":"e_1_2_1_14_1","first-page":"94","article-title":"Detection of total content of flavonoid in the Taraxacum officinale","volume":"24","author":"Jin JL","year":"2001","journal-title":"Yanbian Daxue Yixue Xuebao"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00253-0"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923970009026009"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(76)90747-6"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03714.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00265.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(81)91196-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.3746\/jkfn.2008.37.2.177"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03293.x"},{"key":"e_1_2_1_23_1","first-page":"335","article-title":"Combined effects of plant extracts and xenobiotics on liposomal lipid peroxidation. 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