{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:04:38Z","timestamp":1790283878298,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T00:00:00Z","timestamp":1274140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The extracts and 12 sesquiterpenes obtained from the East African medicinal plant <jats:italic>Warburgia ugandensis<\/jats:italic> Sprague (Canellaceae) were assessed for their antiplasmodial activity against the chloroquine\u2010sensitive (3D7) and chloroquine\u2010resistant (K1) strains of <jats:italic>Plasmodium falciparum<\/jats:italic> and antitrypanosomal activity against <jats:italic>Trypanosoma brucei rhodesiense<\/jats:italic>. The dichloromethane extract displayed strong antiplasmodial and antitrypanosomal activities with IC<jats:sub>50<\/jats:sub> values of 8.10 and 1.10\u2009\u00b5g\/mL against K1 strain of the malaria parasite and STlB900 strain of <jats:italic>T. b. rhodesiense<\/jats:italic>, respectively. Among the compounds evaluated for inhibition of trypomastigotes, both drimane and coloratane sesquiterpenes possessing aldehyde groups at positions 8 and 9 were found to show most antitrypanosomal activity with IC<jats:sub>50<\/jats:sub> values in the range 0.56\u20136.4\u2009\u00b5M. The antiplasmodial assays also revealed that the six coloratane and six drimane sesquiterpenes isolated from this extract exhibited significant antitrypanosomal activity with IC<jats:sub>50<\/jats:sub> values ranged from 0.45 to ?114\u2009\u00b5M. Among the compounds tested against the malarial parasite <jats:italic>P. falciparum<\/jats:italic> 11?\u2010hydroxymuzigadiolide (3) was most active with an IC<jats:sub>50<\/jats:sub> value of 6.40\u2009\u00b5M. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3126","type":"journal-article","created":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T11:06:38Z","timestamp":1274180798000},"page":"1468-1472","source":"Crossref","is-referenced-by-count":35,"title":["Antiprotozoal activity of drimane and coloratane sesquiterpenes towards <i>Trypanosoma brucei rhodesiense<\/i> and <i>Plasmodium falciparum in vitro<\/i>"],"prefix":"10.1002","volume":"24","author":[{"given":"Abraham 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