{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:10:53Z","timestamp":1767917453958,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Four medicinal plants (<jats:italic>Quercus infectoria<\/jats:italic>, <jats:italic>Kaempferia galanga<\/jats:italic>, <jats:italic>Coptis chinensis<\/jats:italic> and <jats:italic>Glycyrrhiza uralensis<\/jats:italic>) as well as one traditional Thai treatment for aphthous ulcers based on these four plants were tested for antimicrobial activity. MIC values for a range of bacteria and <jats:italic>Candida albicans<\/jats:italic> were determined, with both type strains and clinical isolates being used. Antioxidant activity was determined using the ABTS radical scavenging assay. Among the four plants, <jats:italic>Q. infectoria<\/jats:italic> showed antimicrobial activity against <jats:italic>Staphylococcus aureus<\/jats:italic> with an MIC of 0.41\u2009mg\/mL, while <jats:italic>C. chinensis<\/jats:italic> showed antifungal activity against <jats:italic>C. albicans<\/jats:italic> with an MIC of 6.25\u2009mg\/mL. Activity was also shown against a range of other organisms including <jats:italic>Salmonella typhi<\/jats:italic>, <jats:italic>Serratia marcescens<\/jats:italic>, <jats:italic>Vibrio cholerae<\/jats:italic>, <jats:italic>Vibrio parahaemolyticus<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic> and <jats:italic>Enterococcus faecalis<\/jats:italic>. The antimicrobial activity of the traditional aphthous ulcer preparation (a powder) was comparable to that for the individual plant extracts, however, incorporation of the powder into a gel formulation resulted in the loss of almost all activity. All extracts, with the exception of <jats:italic>K. galanga<\/jats:italic>, also showed good antioxidant activity. This study supports the traditional use of these plants and suggests that they may also be useful in the treatment of other infections. 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