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The aim of this study was to determine whether <jats:italic>Cimicifuga racemosa<\/jats:italic> extract BNO 1055 improves metaphyseal fracture healing in severe osteopenic bone in rats.<\/jats:p><jats:p>Thirty\u2010three 12\u2010week\u2010old female rats developed severe osteopenia during 10 weeks after ovariectomy. After metaphyseal tibial\u2010osteotomy and standardized T\u2010plate\u2010osteosynthesis, the healing periods in ovariectomized rats (C), 17\u2010\u03b1\u2010estradiol (E) and <jats:italic>Cimicifuga racemosa<\/jats:italic> (CR) supplemented diets were assessed for 35 days. Changes in callus morphology were evaluated qualitatively by biomechanical testing and quantitatively in microradiographies and fluorochrome\u2010labeled histological sections.<\/jats:p><jats:p>The CR\u2010supplementation slightly improved callus quality and trabecular bone formation. It significantly enhanced the endosteal callus density compared to C group (Cl.Dn.e C: 59.08 \u00b1 21.89, E: 45.95 \u00b1 18.39, CR: 60.85 \u00b1 18.66*), though most of the other morphological parameters examined showed no improvement. The time course of fracture healing did not change due to CR. Estrogen\u2010supplementation enhanced the biomechanical properties of the fracture site. Trabecular bone was improved indicating the physiological endosteal healing process.<\/jats:p><jats:p>The CR\u2010supplementation did not exhibit positive effects in severe (senile) osteopenic fracture healing as seen in early (postmenopausal) osteoporosis in rats. Callus formation was slightly improved under CR. Estrogen improved fracture healing in severe osteopenic bone, while the extent of callus formation played a minor role. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3176","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T15:49:27Z","timestamp":1276789767000},"page":"1796-1806","source":"Crossref","is-referenced-by-count":3,"title":["Absence of positive effect of black cohosh (<i>Cimicifuga racemosa<\/i>) on fracture healing in osteopenic rodent model"],"prefix":"10.1002","volume":"24","author":[{"given":"Leila","family":"Kolios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Daub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Sehmisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Heinz","family":"Frosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Tezval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus Michael","family":"Stuermer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Wuttke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa Klara","family":"Stuermer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2008.08.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14596-5"},{"key":"e_1_2_8_4_1","first-page":"138","article-title":"Estrogen treatment during fracture repair strengthens healing callus in an osteoporotic model","volume":"17","author":"Bolander ME","year":"1992","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0711"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00232-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0843"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf034264r"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.12.2237"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.04.018"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1763-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.040905"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200312000-00005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697130701457729"},{"key":"e_1_2_8_16_1","first-page":"7","article-title":"Gene expression profiling reveals effects of Cimicifuga racemosa (L.) 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