{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:54:07Z","timestamp":1786978447537,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T00:00:00Z","timestamp":1276732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Berberis vulgaris<\/jats:italic>\n                    is a widely used plant for the treatment of urolithiasis. To evaluate its antiurolithic potential, the crude aqueous\u2010methanol extract of\n                    <jats:italic>Berberis vulgaris<\/jats:italic>\n                    root bark (Bv.Cr) was tested in an animal model of urolithiasis, developed in male Wistar rats by adding 0.75% ethylene glycol in drinking water. Bv.Cr (50 mg\/kg) inhibited CaOx crystal deposition in renal tubules and protected against associated changes including polyuria, weight loss, impaired renal function and the development of oxidative stress in kidneys. Activity\u2010guided fractionation revealed the concentration of antiurolithic constituent(s) mainly in the aqueous fraction. These data, indicating the presence of antiurolithic activity in\n                    <jats:italic>Berberis vulgaris<\/jats:italic>\n                    root bark, rationalize its medicinal use for the treatment of urolithiasis. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/ptr.3196","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T11:32:39Z","timestamp":1276774359000},"page":"1250-1255","source":"Crossref","is-referenced-by-count":46,"title":["<i>Berberis vulgaris<\/i>\n                    root bark extract prevents hyperoxaluria induced urolithiasis in rats"],"prefix":"10.1002","volume":"24","author":[{"given":"Samra","family":"Bashir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar H.","family":"Gilani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar 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