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In the present study, the effects of lime (<jats:italic>Citrus aurantifolia<\/jats:italic>) essential oils in reducing body weight, individually and in co\u2010administration with ketotifen, an antihistaminic drug that causes weight\u2010gain, has been investigated using a mouse model. During the 45 days experimental period, the mice that received ketotifen demonstrated an enhancement both in the amount of food intake and body weight compared with the control group. Groups treated with lime essential oil displayed a reduction in body weight and food consumption in mice, possibly through promoting anorexia which might have played a role in weight loss. Interestingly, co\u2010administration of the lime essential oil and ketotifen caused significant suppression in gaining weight, as well as decreased body weights of mice. The data obtained in this study suggested that lime essential oil plays an important role in weight loss and could be useful in the treatment of drug\u2010induced obesity and related diseases. The GC\u2010MS analysis of the essential oils of <jats:italic>C. aurantifolia<\/jats:italic> was also performed and approximately 22 main components, with limonene (28.27%) being the principal one, were identified and quantified. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3227","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T03:13:34Z","timestamp":1278558814000},"page":"1893-1897","source":"Crossref","is-referenced-by-count":50,"title":["Essential Oil from <i>Citrus aurantifolia<\/i> prevents ketotifen\u2010induced weight\u2010gain in mice"],"prefix":"10.1002","volume":"24","author":[{"given":"Solmaz","family":"Asnaashari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Delazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohlol","family":"Habibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roghayeh","family":"Vasfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutfun","family":"Nahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Hamedeyazdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyajit D.","family":"Sarker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,22]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Identification of Essential Oil Component by Gas Chromatography\/Quadrupole Mass spectroscopy","author":"Adams RP.","year":"2004"},{"key":"e_1_2_6_3_1","first-page":"121","article-title":"An animal model of antipsychotic\u2010induced weight gain","volume":"152","author":"Arjona AA","year":"2004","journal-title":"Behav Brain Res"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.12.029"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.10.063"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.1172"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181864a5e"},{"key":"e_1_2_6_8_1","unstructured":"Dr Duke's Phytochemical and Ethnobotanical Databases.2010. 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