{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:34:23Z","timestamp":1772706863517,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two oil\u2010in\u2010water formulations, containing equal amounts of apigenin\u2010enriched chamomile flower extracts, for potential use as topical antiinflammatory agents, were prepared and their physicochemical properties evaluated. A pilot clinical study was then carried out to assess patient acceptability and efficacy. The creams were either non\u2010liposomal or liposomal. The liposomal formulations were more viscous, thus producing superior release characteristics <jats:italic>in vitro<\/jats:italic>. The clinical study also showed that the liposomal creams were, as antiinflammatory agents, slightly more effective <jats:italic>in vivo<\/jats:italic> than the non\u2010liposomal formulations. These results suggest that there is scope for the further development of even more effective and safer alternatives to corticosteroids. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3245","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T13:49:45Z","timestamp":1279288185000},"page":"228-233","source":"Crossref","is-referenced-by-count":38,"title":["Preparation of novel apigenin\u2010enriched, liposomal and non\u2010liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy"],"prefix":"10.1002","volume":"25","author":[{"given":"Ivana","family":"Arsi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanja","family":"Tadi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djordje","family":"Vlaovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Hom\u0161ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Vesi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gorana","family":"Isailovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Vuleta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"17","article-title":"Kamille","author":"Ammon HPT","year":"1996","journal-title":"Dtsch Apoth Z"},{"key":"e_1_2_6_3_1","first-page":"34","article-title":"Galenic principles of modern skin care products","volume":"1","author":"Daniels R","year":"2002","journal-title":"Euro Cosmetics"},{"key":"e_1_2_6_4_1","first-page":"2","article-title":"Basic properties of cosmetic oils and their relevance to emulsion preparations","volume":"125","author":"Dietz T","year":"1999","journal-title":"SOFW J"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.06.032"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.03.002"},{"key":"e_1_2_6_7_1","first-page":"44","volume-title":"Liposome Dermatics","author":"Kerschler JM","year":"1992"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.10.041"},{"key":"e_1_2_6_9_1","first-page":"108","article-title":"Rheology of toiletry products \u2013 physical properties and sensory assessment","volume":"77","author":"Leidereiter H","year":"1996","journal-title":"Perf Cosm"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.05.013"},{"key":"e_1_2_6_11_1","first-page":"69","volume-title":"Liposome Dermatics","author":"Sch\u00e4fer\u2010Korting M","year":"1992"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","unstructured":"ShuklaS GuptaS.2010.Apigenin: a promising molecule for cancer prevention.Pharm Res[Epub ahead of print].","DOI":"10.1007\/s11095-010-0089-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2009.09.007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(03)00183-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.01.049"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.3245","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.3245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.3245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T13:02:05Z","timestamp":1697374925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.3245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1002\/ptr.3245"],"URL":"https:\/\/doi.org\/10.1002\/ptr.3245","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}