{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:14:42Z","timestamp":1762352082490},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Lithraea molleoides<\/jats:italic> (Vell.) Engl. (Anacardiaceae), is known in South America for its medicinal properties: antiarthritic, haemostatic, diuretic, tonic and useful for the treatment of respiratory diseases. Previously the isolation of a new cytotoxic 5\u2010alkyl resorcinol derivative, 1,3\u2010dihydroxy\u20105\u2010(tridec\u20104\u2032,7\u2032\u2010dienyl) benzene, from a dichloromethane extract (DM) was reported. The aim of this work was to determine and to compare the antioxidant activity of DM and the isolated compound, 1,3\u2010dihydroxy\u20105\u2010(tridec\u20104\u2032,7\u2032\u2010dienyl) benzene. Moreover, the activity of both on the proliferation of tumoral and normal lymphocytes was determined. The compound was isolated and quantified by HPLC. The compound represented 0.036% of DM. The extract and the compound exerted antioxidant activity by DPPH and FTC methods. On tumoral cells, both exerted antiproliferative action but the compound was more active (EC<jats:sub>50<\/jats:sub>: 17.4 \u00b1 1\u2009\u00b5g\/mL). On normal lymphocytes, both exerted a stimulatory effect on cell proliferation inversely related to concentration, the extract was more active than the compound (maximum effect: 300 \u00b1 20% of stimulation). Most of the effects observed with the extract were independent of the isolated compound. DM could be an important source of antioxidant and immunomodulatory compounds to be studied on cancer diseases. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3256","type":"journal-article","created":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T05:33:06Z","timestamp":1279690386000},"page":"271-276","source":"Crossref","is-referenced-by-count":11,"title":["Comparative antioxidant activity of an extract of <i>Lithraea molleoides<\/i> and an isolated 5\u2010alkyl resorcinol derivative. Effects on the proliferation of normal and tumoral lymphocytes"],"prefix":"10.1002","volume":"25","author":[{"given":"Paula","family":"L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Anesini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/01634989-199709000-00004","article-title":"Allergic contact dermatitis caused by L. molleoides and L. brasiliensis: identification and characterization of the responsible allergens","volume":"8","author":"Al\u00e9 S","year":"1997","journal-title":"Am J Contact Derm"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8719(98)00038-0"},{"key":"e_1_2_7_4_1","first-page":"329","article-title":"Immunomodulatory activity of Larrea divaricata Cav.","volume":"67","author":"Anesini C","year":"1996","journal-title":"Fitoterapia"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.37.2431"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i37.5959"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/1811199a0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(91)90044-Y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(89)90042-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1078\/09447110260573182"},{"issue":"2","key":"e_1_2_7_11_1","first-page":"3","article-title":"Pentadec\u201010enyl)catechol. A new allergenic compound from L. molleoides (Anacardiaceae)","volume":"20","author":"Gambaro V","year":"1986","journal-title":"Planta Med"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715769809070804"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0010(200102)81:3<353::AID-JSFA826>3.0.CO;2-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(98)00098-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr970464o"},{"key":"e_1_2_7_16_1","first-page":"351","article-title":"Natural amphiphilic phenols as bioactive compounds","volume":"6","author":"Kozubeck A","year":"2001","journal-title":"Cell Mol Biol Lett"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2003.07.013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/12.7.1331"},{"key":"e_1_2_7_19_1","first-page":"671","article-title":"Usos principales de las especies de Anacardiaceae, particularmente del Paraguay","volume":"45","author":"Mu\u00f1oz J.","year":"1990","journal-title":"Candollea"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.5.959"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502051102"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00266-5"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00400-7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0010(199802)76:2<270::AID-JSFA945>3.0.CO;2-9"},{"key":"e_1_2_7_25_1","volume-title":"Plantas Medicinales de la Argentina","author":"Toursarkissian M.","year":"1980"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.3256","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.3256","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.3256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T13:02:45Z","timestamp":1697374965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.3256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1002\/ptr.3256"],"URL":"https:\/\/doi.org\/10.1002\/ptr.3256","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}