{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:18:04Z","timestamp":1772817484600,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,8,24]],"date-time":"2010-08-24T00:00:00Z","timestamp":1282608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aggregated beta\u2010amyloid (A\u03b2) and elevated plasma levels of homocysteine have been implicated as critical factors in the pathogenesis of Alzheimer's disease. The neuroprotective effects and possible mechanism of four structurally similar dibenzocyclooctadiene lignans (namely schisandrin, schisantherin A, schisandrin B and schisandrin C) isolated from the fruit of <jats:italic>Schisandra chinensis<\/jats:italic> (Turcz.) Baill. (Schisandraceae) against A\u03b2<jats:sub>25\u201035<\/jats:sub> and homocysteine toxicity in PC12 cells was studied. Exposure of PC12 cells to 0.5\u2009\u00b5<jats:sc>m<\/jats:sc> A\u03b2<jats:sub>25\u201035<\/jats:sub> caused significant cell death, increased the number of apoptotic cells, elevated reactive oxygen species, increased the levels of the pro\u2010apoptotic protein Bax and caspase\u20103 activation. All these effects induced by A\u03b2<jats:sub>25\u201035<\/jats:sub> were markedly reversed by schisandrin B and schisandrin C pretreatment, while schisandrin and schisantherin A had no obvious effects. Meanwhile, schisandrin B and schisandrin C reversed homocysteine\u2010induced cytotoxicity. The results indicated that schisandrin B and schisandrin C protected PC12 cells against A\u03b2 toxicity by attenuating ROS production and modulating the apoptotic signal pathway through Bax and caspase\u20103. Further structure\u2013activity analysis of Schisandra lignans and evaluations of their neuroprotective effects using AD animal models are warranted. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3269","type":"journal-article","created":{"date-parts":[[2010,8,29]],"date-time":"2010-08-29T19:03:08Z","timestamp":1283108588000},"page":"435-443","source":"Crossref","is-referenced-by-count":57,"title":["Protective effects of dibenzocyclooctadiene lignans from <i>Schisandra chinensis<\/i> against beta\u2010amyloid and homocysteine neurotoxicity in PC12 cells"],"prefix":"10.1002","volume":"25","author":[{"given":"Ju\u2010Xian","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricky Ngok\u2010Shun","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen 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