{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:52:56Z","timestamp":1780545176111,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T00:00:00Z","timestamp":1283990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acne is a chronic inflammatory disorder of skin follicles caused by the gram\u2010positive bacterium <jats:italic>Propionibacterium acnes<\/jats:italic>. The possibility was investigated that a standardized preparation of <jats:italic>Echinacea purpurea<\/jats:italic> (Echinaforce\u00ae), with known antiviral, antiinflammatory and antibacterial properties, might provide a useful alternative treatment in the control of the disease. The herbal extract readily killed a standard laboratory strain of the bacterium and several clinical isolates. In cell culture models of human bronchial epithelial cells and skin fibroblasts, <jats:italic>P. acne<\/jats:italic> induced the secretion of substantial amounts of several pro\u2010inflammatory cytokines, including IL\u20106 and IL\u20108 (CXCL8), as determined by means of cytokine\u2013antibody arrays. However, the <jats:italic>E. purpurea<\/jats:italic> completely reversed this effect and brought the cytokine levels back to normal. Thus Echinaforce\u00ae could provide a safe two\u2010fold benefit to acne individuals by inhibiting proliferation of the organism and reversing the bacterial\u2010induced inflammation. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3288","type":"journal-article","created":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T11:20:03Z","timestamp":1284031203000},"page":"517-521","source":"Crossref","is-referenced-by-count":22,"title":["The potential use of <i>Echinacea<\/i> in acne: control of <i>Propionibacterium acnes<\/i> growth and inflammation"],"prefix":"10.1002","volume":"25","author":[{"given":"M.","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Schoop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Suter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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