{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:05:18Z","timestamp":1790996718213,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T00:00:00Z","timestamp":1290124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Passiflora incarnata<\/jats:italic>\n                    L. (Passifloraceae) is important in herbal medicine for treating anxiety or nervousness, Generalized Anxiety Disorder (GAD), symptoms of opiate withdrawal, insomnia, neuralgia, convulsion, spasmodic asthma, ADHD, palpitations, cardiac rhythm abnormalities, hypertension, sexual dysfunction and menopause. However, the mechanism of action is still under discussion. Despite gaps in our understanding of neurophysiological processes, it is increasingly being recognized that dysfunction of the GABA system is implicated in many neuropsychiatric conditions, including anxiety and depressive disorders. Therefore, the\n                    <jats:italic>in vitro<\/jats:italic>\n                    effects of a dry extract of\n                    <jats:italic>Passiflora incarnata<\/jats:italic>\n                    (sole active ingredient in Pascoflair\u00ae 425\u2009mg) on the GABA system were investigated. The extract inhibited [\n                    <jats:sup>3<\/jats:sup>\n                    H]\u2010GABA uptake into rat cortical synaptosomes but had no effect on GABA release and GABA transaminase activity.\n                    <jats:italic>Passiflora incarnata<\/jats:italic>\n                    inhibited concentration dependently the binding of [\n                    <jats:sup>3<\/jats:sup>\n                    H]\u2010 SR95531 to GABA\n                    <jats:sub>A<\/jats:sub>\n                    \u2010receptors and of [\n                    <jats:sup>3<\/jats:sup>\n                    H]\u2010CGP 54626 to GABA\n                    <jats:sub>B<\/jats:sub>\n                    \u2010receptors. Using the [\n                    <jats:sup>35<\/jats:sup>\n                    S]\u2010GTP\u03b3S binding assay\n                    <jats:italic>Passiflora<\/jats:italic>\n                    could be classified as an antagonist of the GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptor. In contrast, the ethanol\u2010 and the benzodiazepine\u2010site of the GABA\n                    <jats:sub>A<\/jats:sub>\n                    \u2010receptor were not affected by this extract.\n                  <\/jats:p>\n                  <jats:p>\n                    In conclusion, the first evidence was shown that numerous pharmacological effects of\n                    <jats:italic>Passiflora incarnata<\/jats:italic>\n                    are mediated via modulation of the GABA system including affinity to GABA\n                    <jats:sub>A<\/jats:sub>\n                    and GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptors, and effects on GABA uptake. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/ptr.3352","type":"journal-article","created":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T06:41:26Z","timestamp":1290148886000},"page":"838-843","source":"Crossref","is-referenced-by-count":85,"title":["Modulation of the \u03b3\u2010aminobutyric acid (GABA) system by\n                    <i>Passiflora incarnata<\/i>\n                    L."],"prefix":"10.1002","volume":"25","author":[{"given":"Kurt","family":"Appel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Fiebich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kammler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2001.00366.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2001.00367.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.03.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y07-083"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2007.722"},{"key":"e_1_2_7_7_1","first-page":"135","article-title":"Assay 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