{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:37:54Z","timestamp":1766086674847},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T00:00:00Z","timestamp":1297296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea","award":["A091121"],"award-info":[{"award-number":["A091121"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>The roots of <jats:italic>Rhododendron mucronulatum<\/jats:italic> Turzaninov have been used in Oriental traditional medicine for the treatment of dysuria, fever, increase of digestive activity and tonics in China and Korea. Activity guided isolation of the roots of <jats:italic>Rhododendron mucronulatum<\/jats:italic> Turzaninov has led to the isolation of three flavonoids, one flavan 3\u2010ol and one proanthocyanidin. Chemical investigation of the 80% Me<jats:sub>2<\/jats:sub>CO extract from the roots of <jats:italic>Rhododendron mucronulatum<\/jats:italic> led to the isolation and identification of five compounds: taxifolin (1), taxifolin 3\u2010O\u2010\u03b2\u2010<jats:sc>d<\/jats:sc>\u2010glucopyranoside (2), quercetin 3\u2010O\u2010\u03b1\u2010<jats:sc>l<\/jats:sc>\u2010arabinofuranoside (3), (\u2010)\u2010epicatechin (4), procyanidin B\u20103 (5). To investigate the antioxidative and antiinflammatory effects of these compounds, their 1,1\u2010diphenyl\u20102\u2010picrylhydrazyl (DPPH) radical scavenging activities and the protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase\u20102 (COX\u20102) in LPS\u2010stimulated HaCaT cells were also quantified by western blotting and their end products, nitric oxide (NO) and prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>), respectively. Compounds (1\u20135) showed potent DPPH radical scavenging compared with positive controls (<jats:sc>l<\/jats:sc>\u2010ascorbic acid). Also, compounds 1 and 2 dose\u2010dependently inhibited the expressions of inflammatory mediators, NO and PGE<jats:sub>2<\/jats:sub>, suggesting they are promising candidates as antiinflammatory agents. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3376","type":"journal-article","created":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T13:42:15Z","timestamp":1297950135000},"page":"1301-1305","source":"Crossref","is-referenced-by-count":23,"title":["Inhibition of Inducible Nitric Oxide Synthase and Cyclooxygenase\u20102 Expression by Phenolic Compounds from Roots of <i>Rhododendron mucronulatum<\/i>"],"prefix":"10.1002","volume":"25","author":[{"given":"Sun Eun","family":"Choi","sequence":"first","affiliation":[{"name":"College of Pharmacy Chung Ang University  Seoul 156\u2010756 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan Hee","family":"Park","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chung Ang University  Seoul 156\u2010756 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong Hoon","family":"Han","sequence":"additional","affiliation":[{"name":"College 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