{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:27:37Z","timestamp":1770136057736,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T00:00:00Z","timestamp":1296432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science Foundation from Science and Technology Committee of Shanghai Municipality","award":["07DZ12043"],"award-info":[{"award-number":["07DZ12043"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>During industrial processing of Asparagus (<jats:italic>Asparagus officinalis<\/jats:italic> L.), around half of each spear is discarded. However, these discarded asparagus (by\u2010products) might be used as food supplements for their potential therapeutic effects. This study evaluated the hypolipidemic effect of <jats:italic>n<\/jats:italic>\u2010butanol extract (BEA) from asparagus by\u2010products in mice fed a high\u2010fat diet (HFD). Continuous HFD feeding caused hyperlipidemia, oxidative stress and liver damage in mice. Interestingly, while BEA significantly decreased the levels of body weight gain, serum total cholesterol and low density lipoprotein cholesterol, it dramatically increased the high density lipoprotein level when administered at three different doses (40, 80 or 160\u2009mg\/kg body weight) for 8\u2009weeks in hyperlipidemic mice. In addition, BEA decreased the levels of alanine transaminase, aspartate transaminase and alkaline phosphatase in serum. Finally, superoxide dismutase activity and the total antioxidation capacity were evidently increased, while the malondialdehyde level and the distribution of lipid droplets were reduced in liver cells of BEA\u2010treated mice. Taken together, the findings of this study suggested that BEA had a strong hypolipidemic function and could be used as a supplement in healthcare foods and drugs or in combination with other hypolipidemic drugs. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3380","type":"journal-article","created":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T05:19:14Z","timestamp":1311830354000},"page":"1119-1124","source":"Crossref","is-referenced-by-count":25,"title":["Hypolipidemic Effect of <i>n<\/i>\u2010Butanol Extract from <i>Asparagus officinalis<\/i> L. in Mice fed a High\u2010fat Diet"],"prefix":"10.1002","volume":"25","author":[{"given":"Xinglei","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Life Science East China Normal University  3663 North Zhongshan Road Shanghai 200062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science East China Normal University  3663 North Zhongshan Road Shanghai 200062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiufeng","family":"Pang","sequence":"additional","affiliation":[{"name":"School of Life Science East China Normal University  3663 North Zhongshan Road Shanghai 200062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiesi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Science East China Normal University  3663 North Zhongshan Road Shanghai 200062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Life Science East China Normal University  3663 North Zhongshan Road Shanghai 200062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijing","family":"Qu","sequence":"additional","affiliation":[{"name":"School of Life Science East China Normal University  3663 North Zhongshan Road Shanghai 200062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:101:3:219"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.02.038"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf801566r"},{"key":"e_1_2_7_5_1","first-page":"127","volume-title":"Pharmacopoeia of China (Part 3)","author":"Chinese Pharmacopoeia Committee","year":"2005"},{"key":"e_1_2_7_6_1","first-page":"446","article-title":"Purification and monosaccharide composition of saponin from Asparagus officinalis L","volume":"21","author":"Fang YL","year":"2005","journal-title":"Chin J Biotechnol"},{"key":"e_1_2_7_7_1","first-page":"265","article-title":"Effects of asparagus skin on the experimental hyperlipidemia in rats","volume":"21","author":"Feng CP","year":"2001","journal-title":"J Shan Xi Univ"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.12.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86093-B"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.07084"},{"key":"e_1_2_7_11_1","first-page":"15","article-title":"Study on extraction and purification of polysaccharides from stem and leaves of Asparagus officinalis L","volume":"18","author":"Huang XD","year":"2006","journal-title":"Jiangxi J Agric Sci"},{"key":"e_1_2_7_12_1","first-page":"232","article-title":"The therapeutic and preventive experiment of polysaccharide from Seabuckthorn in hyperlipemic mice","volume":"26","author":"Huang XQ","year":"2004","journal-title":"Acta Nutr Sin"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00219-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.73"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00287-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.280.4.C719"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.09.057"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2005.10.011"},{"key":"e_1_2_7_19_1","unstructured":"National Research Council.1985.Guide for the Care and Use of Laboratory Animals(NIH Publication No. 85\u201323). 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