{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:43:57Z","timestamp":1789785837118,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T00:00:00Z","timestamp":1296432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p><jats:italic>Campylobacter jejuni<\/jats:italic> is one of the most common bacterial causes of diarrhoea in the industrialized world, being associated with the occurrence of Guillain\u2010Barr\u00e9 Syndrome, and inducing diseases partially through intestinal adherence. With increasing reports of <jats:italic>C. jejuni<\/jats:italic> drug resistance against standard antibiotics, investigations into antiadhesive agents for the prevention of bacterial infection are highly significant. Given the consumer\u2010driven development towards holistic and integrative healthcare, research into additional anti\u2010<jats:italic>Campylobacter<\/jats:italic> effects of herbal medicines that are already used for their beneficial effects on bowel and digestive functions is important.<\/jats:p><jats:p>Twenty\u2010one herbal extracts were screened for antiadhesive activity against <jats:italic>C. jejuni<\/jats:italic> using modifications of previously published antiadhesion assays. Antiadhesion effects with IC<jats:sub>50<\/jats:sub> values &lt;3\u2009mg\/mL were obtained for seven ethanol plant extracts, with <jats:italic>Zingiber officinale<\/jats:italic> (ginger), <jats:italic>Capsicum annum<\/jats:italic> (cayenne) and <jats:italic>Glycyrrhiza glabra<\/jats:italic> (licorice) displaying the highest antiadhesion activity against <jats:italic>C. jejuni<\/jats:italic> (IC<jats:sub>50<\/jats:sub>: &lt;0.1\u2009mg\/mL, 0.29\u2009mg\/mL and 0.65\u2009mg\/mL, respectively). Differences in antiadhesion activity were found for two different Echinacea species, with <jats:italic>E. purpurea<\/jats:italic> displaying significantly higher and dose dependent antiadhesion activity than <jats:italic>E. angustifolia<\/jats:italic>. No significant antiadhesion activity (IC<jats:sub>50<\/jats:sub> values &gt;35\u2009mg\/mL) was found for <jats:italic>Agrimonia eupatoria<\/jats:italic> (agrimony), <jats:italic>Andrographis paniculata<\/jats:italic> (andrographis), <jats:italic>Matricaria recutita<\/jats:italic> (chamomile), <jats:italic>Foeniculum vulgare<\/jats:italic> (fennel), <jats:italic>Filipendula ulmaria<\/jats:italic> (meadowsweet) and <jats:italic>Artemisia absinthium<\/jats:italic> (wormwood) extracts.<\/jats:p><jats:p>This study provides evidence for additional beneficial effects of marketed herbal medicines in gastrointestinal disorders. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3384","type":"journal-article","created":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T05:19:14Z","timestamp":1311830354000},"page":"1125-1132","source":"Crossref","is-referenced-by-count":31,"title":["Investigations into the Antiadhesive Activity of Herbal Extracts Against <i>Campylobacter jejuni<\/i>"],"prefix":"10.1002","volume":"25","author":[{"given":"K.","family":"Bensch","sequence":"first","affiliation":[{"name":"School of Pharmacy Griffith University, Gold Coast Campus  Queensland 4222 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tiralongo","sequence":"additional","affiliation":[{"name":"Institute for Glycomics Gold Coast Campus  Queensland 4222 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"School of Pharmacy Griffith University, Gold Coast Campus  Queensland 4222 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Matthias","sequence":"additional","affiliation":[{"name":"Integria Healthcare  8 Clunies Ross Court, Eight Mile Plains Brisbane Queensland 4113 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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