{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:09:14Z","timestamp":1791252554521,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T00:00:00Z","timestamp":1296432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>The aim of the present study was to clarify the <jats:italic>in vitro<\/jats:italic> potential of the purified Chinese herbal constituents LZX\u2010A (neferine), QTJ (sinomenine), YHS (tetrahydropalmitine) and SQZG (notoginsenoside R1) to displace the highly bound bilirubin from albumin binding sites in plasma from jaundiced newborn infants. Sulfisoxazole (1.32\u2009m<jats:sc>m<\/jats:sc>) was used as a positive control for bilirubin displacement. The displacing potential of the herbal constituents was investigated at assumed therapeutic concentrations and up to 100 times higher. Total (TB) and unbound (UB) bilirubin in plasma were measured by the peroxidase method. Sulfisoxazole increased the UB concentration in plasma by more than 60%. An increased % displacement of bilirubin was found at higher TB levels confirming the presence also of lower affinity binding sites for bilirubin in plasma. None of the purified herbal constituents showed any bilirubin displacing properties and were unaffected by the level of TB in plasma. The combination of sulfisoxazole and the herbal constituents showed no synergistic effect. It is concluded that none of the investigated purified herbal constituents possess any significant potential <jats:italic>in vitro<\/jats:italic> to increase the UB concentration in plasma from jaundiced newborn infants. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3402","type":"journal-article","created":{"date-parts":[[2011,12,9]],"date-time":"2011-12-09T09:36:04Z","timestamp":1323423364000},"page":"1068-1072","source":"Crossref","is-referenced-by-count":7,"title":["Displacement of Bilirubin from Albumin in Plasma from Jaundiced Newborns. An <i>In Vitro<\/i> Study of Purified Chinese Herbal Constituents and Sulfisoxazole"],"prefix":"10.1002","volume":"25","author":[{"given":"Hanne Tegnander","family":"Soligard","sequence":"first","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine Faculty of Medicine, Norwegian University of Science and Technology (NTNU)  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Bratlid","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine Norwegian University of Science and Technology (NTNU)  Trondheim Norway"},{"name":"Department of Pediatrics and Adolescent Medicine St Olavs University Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences (CACMS)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences (CACMS)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odd Georg","family":"Nilsen","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine Faculty of Medicine, Norwegian University of Science and Technology (NTNU)  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.2000.4485"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2004.09.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1542\/peds.18.4.614","article-title":"A difference in mortality rate and incidence of kernicterus among premature infants allotted to two prophylactic antibacterial regimens","volume":"18","author":"Andersen DH","year":"1956","journal-title":"Pediatrics"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365517209081098"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365517209084298"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30578-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107882"},{"key":"e_1_2_7_9_1","first-page":"522","article-title":"A review of the pharmacology study and clinical application of rhizome corydalis","volume":"20","author":"Fan Z","year":"2007","journal-title":"Heilongjiang Med J"},{"key":"e_1_2_7_10_1","first-page":"197","article-title":"Review on study of total saponins of panax notognseng","volume":"8","author":"Han Y","year":"2005","journal-title":"China Pharm"},{"key":"e_1_2_7_11_1","unstructured":"FDA Guidelines.2008.http:\/\/www.fda.gov\/cber\/gdlns\/dose.htm\/April2008"},{"key":"e_1_2_7_12_1","first-page":"105","article-title":"Study on pharmacokinetics of neferine in rabbit","volume":"13","author":"Hu X","year":"1993","journal-title":"Chin J Hosp Pharm"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/clinchem\/20.7.783","article-title":"Determination of unbound bilirubin in the serum of newborns","volume":"20","author":"Jacobsen J","year":"1974","journal-title":"Clin Chem"},{"key":"e_1_2_7_14_1","first-page":"247","article-title":"Review on the study of sinomenine","volume":"28","author":"Liu Q","year":"1997","journal-title":"Chin Tradit Herb Drugs"},{"key":"e_1_2_7_15_1","first-page":"299","article-title":"A review of study of sinomenine","volume":"1","author":"Long X.","year":"2003","journal-title":"Central South Pharmacy"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(78)90411-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.945"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00648.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199324020-00007"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103864"},{"key":"e_1_2_7_21_1","first-page":"16","article-title":"The distribution and toxicity of bilirubin. E. Mead Johnson address 1969","volume":"46","author":"Odell GB.","year":"1970","journal-title":"Pediatrics"},{"key":"e_1_2_7_22_1","first-page":"13","article-title":"Study on pharmacokinetics of tetrahydropalmatine in rabbit plasma","volume":"15","author":"Pang Z","year":"1995","journal-title":"Chin J Pharm Anal"},{"key":"e_1_2_7_23_1","first-page":"112","article-title":"Determination of notoginsenoside R1, ginsenoside Rg1 and Rb1in radix notoginseng and its preparation by HPLC\u2010ELSD","volume":"30","author":"Sha DX","year":"2005","journal-title":"Chin J Chin Mater Med"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(88)90004-7"},{"key":"e_1_2_7_25_1","first-page":"8","article-title":"Review on the pharmacological research of neferine","volume":"20","author":"Tang XQ","year":"2004","journal-title":"Chin Pharmacol Bull"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.10090"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104628200"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0395"},{"key":"e_1_2_7_29_1","unstructured":"WHO.2002.WHO Traditional Medicine Strategy 2002\u20132005. WHO\/EDM\/TRM\/2002.1. World Health Organization: Geneva."},{"key":"e_1_2_7_30_1","first-page":"60","article-title":"Study progress of clinical application of tetrahydropalmatine","volume":"14","author":"Xu T","year":"2002","journal-title":"Acta Univ Trad Med Sinen Pharmacol Shanghai"},{"key":"e_1_2_7_31_1","first-page":"620","article-title":"Determination of sinomenine HCl in serum and urine by HPLC and its pharmacokinetics in normal volunteers","volume":"32","author":"Yan XH","year":"1997","journal-title":"Acta Pharm Sin"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000243239"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1993.tb00514.x"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.3402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.3402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.3402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T22:19:37Z","timestamp":1698790777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.3402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,31]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1002\/ptr.3402"],"URL":"https:\/\/doi.org\/10.1002\/ptr.3402","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,31]]}}}