{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:53:33Z","timestamp":1768445613626,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,2,7]],"date-time":"2011-02-07T00:00:00Z","timestamp":1297036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"School of Graduate Studies, Addis Ababa University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>The effect of the leaf extract of <jats:italic>Plantago lanceolata<\/jats:italic> L. (Plantaginaceae) on gastric secretion and cytoprotection was evaluated using different models of gastroduodenal ulcer, including acetic acid induced chronic gastric ulcer, indomethacin induced gastric ulcer, cysteamine induced duodenal ulcer and pylorus ligation induced gastric ulcer. The aqueous extract was administered at 200\u2009mg\/kg and 400\u2009mg\/kg and 140\u2009mg\/kg and 280\u2009mg\/kg for mice and rats, respectively, and compared with vehicle or the standard, ranitidine (50 or 70\u2009mg\/kg) or misopristol (280\u2009\u03bcg\/kg). In addition, activity of the mucilage (172\u2009mg\/kg) was also evaluated in acetic acid induced chronic gastric ulcer. Administration was done orally except in pylorus ligation, where the intraduodenal route was used. In all cases, higher doses of the extract provided better protection than lower doses and the mucilage, hinting at a dose\u2010dependent effect. Whilst higher doses of the extract showed a better healing of the ulcer as well as protection in indomethacin and pylorus ligation models, activities of lesser magnitude than ranitidine were noted in the cysteamine model. Together these findings indicate that higher doses used in the present study provided an overall better protection against gastroduodenal ulcers than the standard drugs employed through antisecretory and cytoprotective mechanisms. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3411","type":"journal-article","created":{"date-parts":[[2011,2,13]],"date-time":"2011-02-13T12:21:10Z","timestamp":1297599670000},"page":"1174-1180","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of the Antipeptic Ulcer Activity of the Leaf Extract of <i>Plantago lanceolata<\/i> L. in Rodents"],"prefix":"10.1002","volume":"25","author":[{"given":"Endale","family":"Melese","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Pharmacy Addis Ababa University  Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaleab","family":"Asres","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy School of Pharmacy Addis Ababa University  Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Asad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy Addis Ababa University  Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ephrem","family":"Engidawork","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy Addis Ababa University  Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-8741(00)00212-9","article-title":"The traditional uses, chemical constituents and biological activities of Plantago major L. 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