{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:50:22Z","timestamp":1771267822012,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T00:00:00Z","timestamp":1296691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p><jats:italic>Vaccinium myrtillus<\/jats:italic> L. anthocyanoside (VMA) is used as a folk medicine to treat diseases related to gastric ulcers in northern Europe. However, the effects of VMA and its detailed mechanism on gastric ulcer have not been investigated sufficiently. Therefore, the aim of the present study was to investigate the protective effects of VMA on gastric mucosal damage in a murine gastric ulcer model. First the effects of VMA on ethanol\u2010induced gastric ulcers in mice were investigated. Then, the levels of lipid peroxide in murine stomach homogenates were measured to investigate the antioxidative effects of VMA. In addition, the free radical scavenging activity of VMA and its main anthocyanidins were evaluated by electron spin resonance measurement. Oral administration of VMA (10, 30 and 100\u2009mg\/kg) significantly protected gastric mucosa against HCl\/ethanol\u2010induced gastric ulcers. Furthermore, VMA inhibited lipid peroxide levels in a concentration\u2010dependent manner and showed high scavenging activity against the superoxide anion radical (\u00b7O<jats:sub>2<\/jats:sub><jats:sup>\u2010<\/jats:sup>) and the hydroxyl radical (\u00b7OH). Anthocyanidins also showed scavenging activity against the \u00b7O<jats:sub>2<\/jats:sub><jats:sup>\u2010<\/jats:sup>, while only delphinidin showed high scavenging activity against the \u00b7OH. These findings indicate that the protective effects of VMA on HCl\/ethanol\u2010induced gastric mucosal injury may be partially due to the antiperoxidative effects of anthocyanidins. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3413","type":"journal-article","created":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T05:19:14Z","timestamp":1311830354000},"page":"1160-1165","source":"Crossref","is-referenced-by-count":29,"title":["The Protective Effect and Action Mechanism of <i>Vaccinium myrtillus<\/i> L. on Gastric Ulcer in Mice"],"prefix":"10.1002","volume":"25","author":[{"given":"Kenjirou","family":"Ogawa","sequence":"first","affiliation":[{"name":"Molecular Pharmacology, Department of Biofunctional Evaluation Gifu Pharmaceutical University  Gifu 501\u20101196 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Oyagi","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology, Department of Biofunctional Evaluation Gifu Pharmaceutical University  Gifu 501\u20101196 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology, Department of Biofunctional Evaluation Gifu Pharmaceutical University  Gifu 501\u20101196 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Wakasa Seikatsu Co. 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