{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:54:27Z","timestamp":1789674867297,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T00:00:00Z","timestamp":1297900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DST"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p><jats:italic>Calotropis procera<\/jats:italic> (family: Apocynaceae) is a plant growing in the wild and has been used in the traditional medicinal system for the treatment of various diseases. The plant produces milky latex that possesses potent antiinflammatory and analgesic properties. In present study the non\u2010dialysable protein fraction isolated from the latex (LP) of this plant was evaluated for its efficacy against inflammation in rats where paw edema was induced by sub\u2010plantar injection of carrageenin or monoarthritis was induced by intra\u2010articular injection of Freund's complete adjuvant (FCA). The effect of LP was evaluated on edema volume in the paw model and on joint diameter, stair climbing ability, motility, dorsal flexion pain, levels of oxidative stress markers and joint histology in arthritis model. The protection afforded by LP was compared with that of standard antiinflammatory drug, diclofenac (5\u2009mg\/kg). LP exhibited a dose\u2010dependent antiinflammatory effect and produced 32% and 60% inhibition of paw edema at 10 and 25\u2009mg\/kg doses and 12% and 36% inhibition of joint inflammation at 50 and 150\u2009mg\/kg doses. The protective effect of LP was associated with normalization of joint functions, histology and levels of oxidative stress markers in joint tissue. The findings of this study suggest that the protein fraction of latex of <jats:italic>Calotropis procera<\/jats:italic> has the potential to relieve inflammation and pain associated with various arthritic conditions. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3428","type":"journal-article","created":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T16:19:25Z","timestamp":1298564365000},"page":"1336-1341","source":"Crossref","is-referenced-by-count":32,"title":["Protective Effect of Proteins Derived from the Latex of <i>Calotropis procera<\/i> against Inflammatory Hyperalgesia in Monoarthritic Rats"],"prefix":"10.1002","volume":"25","author":[{"given":"Vijay L.","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmacology All India Institute of Medical Sciences  Ansari Nagar New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Plant Molecular Biology Delhi University South Campus  Benito Juarez Road, Dhaula Kuan New Delhi 110021 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio V.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Departmento de Bioquimica de Biologia Molecular Universidade Federal do Ceara  Campus do Pici, Cx. 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