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In this study, the antidepressant effect of L\u2010theanine was investigated in mice using the forced swim test, tail suspension test, open\u2010field test and reserpine test. L\u2010theanine produced an antidepressant\u2010like effect, since the administration of L\u2010theanine at doses of 1, 4 and 20\u2009mg\/kg for 10 successive days significantly reduced the immobility time in both the forced swim test and tail suspension test, compared with the control group, without accompanying changes in ambulation in the open\u2010field test. Moreover, L\u2010theanine significantly antagonized reserpine\u2010induced ptosis and hypothermia. Taken together, these results indicate that L\u2010theanine possessed an antidepressant\u2010like effect in mice, which may be mediated by the central monoaminergic neurotransmitter system. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3456","type":"journal-article","created":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T14:06:34Z","timestamp":1300716394000},"page":"1636-1639","source":"Crossref","is-referenced-by-count":58,"title":["Antidepressant\u2010like Effects of L\u2010theanine in the Forced Swim and Tail Suspension Tests in Mice"],"prefix":"10.1002","volume":"25","author":[{"given":"Cui","family":"Yin","sequence":"first","affiliation":[{"name":"School of Pharmacy Xuzhou Medical College  84 West Huai'hai Road Xuzhou Jiangsu 221002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingshan","family":"Gou","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xuzhou Medical College  84 West Huai'hai Road Xuzhou Jiangsu 221002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xuzhou Medical College  84 West Huai'hai Road Xuzhou Jiangsu 221002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xuzhou Medical College  84 West Huai'hai Road Xuzhou Jiangsu 221002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xuzhou Medical College  84 West Huai'hai Road Xuzhou Jiangsu 221002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genguang","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xuzhou Medical College  84 West Huai'hai Road Xuzhou Jiangsu 221002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zhuang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xuzhou Medical College  84 West Huai'hai Road Xuzhou Jiangsu 221002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2006.03.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.03.014"},{"key":"e_1_2_7_4_1","first-page":"1173","article-title":"The value of the reserpine test in psychopharmacology","volume":"33","author":"Bourin M","year":"1983","journal-title":"Arzneim Forsch Drug Res"},{"key":"e_1_2_7_5_1","first-page":"519","article-title":"Development of antidepressant drugs. 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