{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:54:07Z","timestamp":1786978447516,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,3,31]],"date-time":"2011-03-31T00:00:00Z","timestamp":1301529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>\n                    In the search for new antimicrobial and antioxidant compounds from plants, the latex of the medicinal plant\n                    <jats:italic>Aloe harlana<\/jats:italic>\n                    Reynolds from Ethiopia was subjected to bioassay\u2010guided fractionation, which led to the isolation of two known compounds, anthrone (aloin) and chromone (7\u2010O\u2010methylaloeresin A). The latex and its two constituents were assessed for their possible antimicrobial activities against 23 bacterial and four fungal strains using the disc diffusion method and their antioxidant activity by two complementary test systems, namely 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) and 2\u2010deoxyribose degradation assay methods.\n                  <\/jats:p>\n                  <jats:p>\n                    The isolated compounds showed promising results against various pathogenic bacterial and fungal strains in comparison with standard drugs. Moreover, 7\u2010O\u2010methylaloeresin A exhibited good activity against multiple drug resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (NCTC 11994) and\n                    <jats:italic>Salmonella typhimurium<\/jats:italic>\n                    (ATCC 1255) with MIC values of 0.72 and 0.18\u2009m\n                    <jats:sc>m<\/jats:sc>\n                    , respectively. Among the fungal strains tested,\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    (ATCC 10231) was the most susceptible organism to the latex and the two isolated compounds. The latex and isolated compounds also showed significant activities on both antioxidant assays with the highest activity being observed for 7\u2010O\u2010methylaloeresin A, which gave IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.026\u2009m\n                    <jats:sc>m<\/jats:sc>\n                    and 0.021\u2009m\n                    <jats:sc>m<\/jats:sc>\n                    for DPPH and 2\u2010deoxyribose degradation assay, respectively. These findings support the traditional uses of the plant for the treatment of various infectious and inflammatory diseases. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/ptr.3482","type":"journal-article","created":{"date-parts":[[2011,3,31]],"date-time":"2011-03-31T04:03:36Z","timestamp":1301544216000},"page":"1756-1760","source":"Crossref","is-referenced-by-count":76,"title":["<i>In Vitro<\/i>\n                    Antimicrobial and Antioxidant Activities of Anthrone and Chromone from the Latex of\n                    <i>Aloe harlana<\/i>\n                    Reynolds"],"prefix":"10.1002","volume":"25","author":[{"given":"Gelila","family":"Asamenew","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry and Pharmacognosy School of Pharmacy Addis Ababa University  P.O. Box 1176 Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bisrat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry and Pharmacognosy School of Pharmacy Addis Ababa University  P.O. Box 1176 Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avijit","family":"Mazumder","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology Noida Institute of Engineering and Technology  19 Knowledge Park II, Institutional Area, Greater Noida\u2010201306 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaleab","family":"Asres","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry and Pharmacognosy School of Pharmacy Addis Ababa University  P.O. Box 1176 Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(03)00268-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)00328-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19970800411"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)94771-X"},{"key":"e_1_2_7_6_1","first-page":"117","volume-title":"Flora of Ethiopia and Eritrea","author":"Demissew S","year":"1997"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90222-3"},{"key":"e_1_2_7_8_1","unstructured":"HechtDW CitronDM CoxMet al.2006.Method for Antimicrobial Susceptibility Testing of Anaerobic Bacteria. Approved standard\u2010seventh edition. Clinical and LaboratoryStandards Institute:Wayne PA;27:2. 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