{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:17:49Z","timestamp":1788351469213,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,6,8]],"date-time":"2011-06-08T00:00:00Z","timestamp":1307491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>Extracts from <jats:italic>Serenoa repens<\/jats:italic> are widely used for the treatment of benign prostatic hyperplasia (BPH) and traditionally for prostatitis. In the present study we evaluated the biological effects of <jats:italic>Serenoa repens<\/jats:italic> extract (Prostasan\u00ae) on prostate cells beyond its known antiandrogenic actions. Prostasan\u00ae inhibited epidermal growth factor (EGF) and lipopolysaccharide (LPS) induced proliferation of the prostatic epithelial, androgen independent cell line PC\u20103. At effective concentrations of 50\u2009\u00b5g\/mL, Prostasan\u00ae partly displaced EGF from EGF receptor (EGFR) but fully blocked EGF\u2010induced cell proliferation of PC\u20103 cells. Similarly, Prostasan\u00ae inhibited LPS\u2010induced proliferation of PC\u20103 cells without affecting LPS activation of the NF<jats:italic>\u0138<\/jats:italic>B pathway via toll\u2010like receptor\u20104 (TLR\u20104). Additionally, Prostasan\u00ae reduced the constitutive secretion of monocyte chemotactic protein\u20101 (MCP\u20101), the LPS\u2010induced secretion of IL\u201012 and inhibited MCP\u20101 and granulocyte\u2010macrophage colony\u2010stimulating factor (GM\u2010CSF) production in the presence of LPS on PC\u20103 cells. Taken together, our results suggest that <jats:italic>S. repens<\/jats:italic> extracts, in addition to other reported effects on BPH development and prostatitis, inhibits EGF\u2010dependent growth and proinflammatory responses of the prostate epithelial cells. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3537","type":"journal-article","created":{"date-parts":[[2011,6,8]],"date-time":"2011-06-08T08:22:50Z","timestamp":1307521370000},"page":"259-264","source":"Crossref","is-referenced-by-count":20,"title":["Androgen\u2010independent Effects of <i>Serenoa repens<\/i> Extract (Prostasan\u00ae) on Prostatic Epithelial Cell Proliferation and Inflammation"],"prefix":"10.1002","volume":"26","author":[{"given":"Diego","family":"Iglesias\u2010Gato","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Hospital, Karolinska Institutet  171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tober","family":"Carsten","sequence":"additional","affiliation":[{"name":"Rent\u2010a\u2010lab  72 770 Reutlingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Vesterlund","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Hospital, Karolinska Institutet  171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ake","family":"Pousette","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Hospital, Karolinska Institutet  171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Schoop","sequence":"additional","affiliation":[{"name":"A. 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