{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:32:14Z","timestamp":1775039534499,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T00:00:00Z","timestamp":1308009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>Du\u2010Zhong is one of the most important tonic herbs in traditional Chinese medicine for the treatment of bone fractures and other bone diseases. The present study examined whether Du\u2010Zhong seed extract named total glycosides from <jats:italic>Eucommia ulmoides<\/jats:italic> seed (TGEUS) could display an increased effect on bone density and bone strength of the femur in rats. Sprague\u2013Dawley rats were used and randomly assigned to the normal group and the TGEUS group (400\u2009mg\/kg body weight\/day). Daily oral administration of TGEUS was found to increase significantly the biomechanical quality of the femur. The mechanical changes were associated with a bone mineral density (BMD) increase or even with some improvements in microarchitecture. Micro\u2010CT analysis of the distal femur showed that TGEUS significantly increased the bone volume\/tissue volume (BV\/TV), connectivity density (Conn.D), trabecular number (Tb.N) and trabecular thickness (Tb.Th), and decreased trabecular separation (Tb.Sp) and the structure model index (SMI) in normal rats. To conclude, TGEUS taken orally increased bone density and altered bone histomorphology, suggesting that TGEUS might be a potential alternative medicine for the treatment of postmenopausal osteoporosis. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3543","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T14:25:39Z","timestamp":1308061539000},"page":"1895-1897","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Total Glycosides from <i>Eucommia ulmoides<\/i> Seed on Bone Microarchitecture in Rats"],"prefix":"10.1002","volume":"25","author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[{"name":"Biomedicine Key Laboratory of Shaanxi Province Northwest University  Xi'an Shaanxi 710069 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention of Shaanxi Province  Xi'an Shaanxi 710054 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Li","sequence":"additional","affiliation":[{"name":"Biomedicine Key Laboratory of Shaanxi Province Northwest University  Xi'an Shaanxi 710069 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie\u2010Paris 6 Institut Parisien de Chimie Mol\u00e9culaire, UMR 7201  4 place Jussieu 75005 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Zhao","sequence":"additional","affiliation":[{"name":"Biomedicine Key Laboratory of Shaanxi Province Northwest University  Xi'an Shaanxi 710069 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u2010ming","family":"Xie","sequence":"additional","affiliation":[{"name":"Biomedicine Key Laboratory of Shaanxi Province Northwest University  Xi'an Shaanxi 710069 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010ji","family":"Sun","sequence":"additional","affiliation":[{"name":"Biomedicine Key Laboratory of Shaanxi Province Northwest University  Xi'an Shaanxi 710069 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02980202"},{"key":"e_1_2_6_3_1","first-page":"1069","article-title":"Dose conversion among different animals and healthy volunteers in pharmacological study","volume":"9","author":"Huang JH","year":"2004","journal-title":"Chin J Clin Pharmacol Ther"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2009.08.021"},{"key":"e_1_2_6_5_1","first-page":"33","article-title":"Regeneration of recovered bark in Eucommia ulmoides","volume":"26","author":"Li ZL","year":"1983","journal-title":"Chem Biol Agric Med Earth Sci"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.02.025"},{"key":"e_1_2_6_7_1","first-page":"523632","article-title":"Use of total glycoside from Eucommia ulmoides seed in preparation of medicine for treating osteoporosis. 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