{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:03:19Z","timestamp":1759960999531,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T00:00:00Z","timestamp":1311206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002465","name":"Daejeon University","doi-asserted-by":"crossref","award":["TBRC 05-06-02"],"award-info":[{"award-number":["TBRC 05-06-02"]}],"id":[{"id":"10.13039\/501100002465","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:italic>Duchesnea chrysantha<\/jats:italic> belongs to the Rosaceae family and has been used traditionally for the treatment of various diseases in Korea and other parts of East Asia. This study examined the antiinflammatory effect of <jats:italic>Duchesnea chrysantha<\/jats:italic> extract (DcE) on atopic dermatitis <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. DcE inhibited the production of IL\u20106, IL\u20108 and MCP\u20101 in THP\u20101 cells and the release of IL\u20106 and MCP\u20101 in EoL\u20101 cells after treatment with house dust mite extract. In the <jats:italic>in vivo<\/jats:italic> experiment, Nc\/Nga mice were sensitized to DNCB and then orally and dorsally administered DcE (50\u2009mg\/kg in PBS) for 3\u2009weeks. The DcE administration significantly reduced the skin severity score when compared with the control group and inhibited the thickening of the epidermis and infiltration of inflammatory cells into the dermis. In addition, the serum IgE levels decreased markedly in the DcE\u2010treated mice when compared with the control group. The synthesis of IL\u20105, IL\u201013, MCP\u20101 and eotaxin was also decreased in splenocytes of the DcE\u2010treated group, while IFN\u2010\u03b3 was increased in the Dc\u2010administered group. These results may indicate that DcE attenuates the development of atopic dermatitis\u2010like lesions by lowering the IgE and inflammatory cytokine levels, and that it is useful in drug development for the treatment of atopic dermatitis. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3545","type":"journal-article","created":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T06:14:41Z","timestamp":1311228881000},"page":"284-290","source":"Crossref","is-referenced-by-count":10,"title":["The Inhibitory Effect of <i>Duchesnea chrysantha<\/i> Extract on the Development of Atopic Dermatitis\u2010like Lesions by Regulating IgE and Cytokine Production in Nc\/Nga Mice"],"prefix":"10.1002","volume":"26","author":[{"given":"Ji\u2010Sook","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Science Wonkwang Health Science University  Iksan 570\u2010750 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science School of Medicine, Eulji University  Daejeon 301\u2010832 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