{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T08:29:15Z","timestamp":1721377755647},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T00:00:00Z","timestamp":1308787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p><jats:italic>Ganoderma lucidum<\/jats:italic> (GL), an oriental medical mushroom, has been used in Asia for the prevention and treatment of a variety of diseases. However, the effect of GL on allergic rhinitis has not been well defined. The current study describes the inhibitory effect of GL on the biphasic nasal blockage and nasal hyperresponsiveness induced by repeated antigen challenge in a guinea pig model of allergic rhinitis. Intranasally sensitized guinea pigs were repeatedly challenged by inhalation of Japanese cedar pollen once every week. <jats:italic>Ganoderma lucidum<\/jats:italic> was orally administered once daily for 8\u2009weeks from the time before the first challenge. The treatment with GL dose\u2010dependently inhibited the early and late phase nasal blockage at the fifth to ninth antigen challenges. Furthermore, nasal hyperresponsiveness to intranasally applied leukotriene D<jats:sub>4<\/jats:sub> on 2\u2009days after the eighth antigen challenge was also inhibited by the treatment with GL. However, Cry j 1\u2010specific IgE antibody production was not affected by the treatment. In conclusion, we demonstrated that the pollen\u2010induced biphasic nasal blockage and nasal hyperresponsiveness were suppressed by the daily treatment with GL in the guinea pig model of allergic rhinitis. These results suggest that GL may be a useful therapeutic drug for treating patients with allergic rhinitis. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3557","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T09:50:54Z","timestamp":1308822654000},"page":"325-332","source":"Crossref","is-referenced-by-count":6,"title":["Effect of <i>Ganoderma lucidum<\/i> on Pollen\u2010induced Biphasic Nasal Blockage in a Guinea Pig Model of Allergic Rhinitis"],"prefix":"10.1002","volume":"26","author":[{"given":"Nobuaki","family":"Mizutani","sequence":"first","affiliation":[{"name":"Department of Pharmacology Kobe Pharmaceutical University  4\u201019\u20101 Motoyamakita Higashinada Kobe 658\u20108558 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nabe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kyoto Pharmaceutical University  5 Nakauchi, Misasagi Yamashina Kyoto 607\u20108414 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