{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:26:39Z","timestamp":1790364399880,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T00:00:00Z","timestamp":1309392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>Recently, the isolation of several condensed tannins from the roots of <jats:italic>Rosa multiflora<\/jats:italic> Thunberg, a traditional herbal therapy in oriental medicine for rheumatoid arthritis and scabies, was described. Two of the major condensed tannins \u2013 procyanidin B\u20103 (ProB3) and <jats:italic>ent<\/jats:italic>\u2010guibourtinidol\u2010(4<jats:italic>\u03b2<\/jats:italic>\u2009\u2192\u20096)\u2010catechin (RM\u20101) \u2013 were then applied topically to atopic dermatitis\u2010like skin lesions on NC\/Nga mice in order to assess their immunomodulatory properties. Both ProB3 and RM\u20101 significantly reduced the serum levels of eosinophils, IgE and certain Th2 cytokines (IL\u20104, 5 and 13) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 or 0.01). Additionally, ProB3 and RM\u20101 significantly reduced both the mRNA and protein expression of COX\u20102 and iNOS in mouse skin tissues (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Such results strongly suggest that ProB3 and RM\u20101 may be useful in the treatment allergic skin conditions, most notably atopic dermatitis. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3578","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T15:25:43Z","timestamp":1309447543000},"page":"1564-1569","source":"Crossref","is-referenced-by-count":19,"title":["Topical Application of Two Condensed Tannins from the Root of <i>Rosa multiflora<\/i> Thunberg for the Treatment of Atopic Dermatitis (AD) in NC\/Nga Mice"],"prefix":"10.1002","volume":"25","author":[{"given":"Kwan Hee","family":"Park","sequence":"first","affiliation":[{"name":"College of Pharmacy Chung\u2010Ang University  Seoul 156\u2010756 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Eun","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chung\u2010Ang University  Seoul 156\u2010756 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young 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