{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:27:07Z","timestamp":1767850027185,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T00:00:00Z","timestamp":1314921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>This clinical research study was designed to evaluate the efficacy of a new herbal product, EstroG\u2010100, containing a mixture of standardized extracts of <jats:italic>Cynanchum wilfordii<\/jats:italic>, <jats:italic>Phlomis umbrosa<\/jats:italic> and <jats:italic>Angelica gigas<\/jats:italic>, on menopausal symptoms. This randomized double\u2010blind, placebo\u2010controlled trial was performed for 12\u2009weeks with 64 pre\u2010, peri\u2010 and postmenopausal White Hispanic, White non\u2010Hispanic and African American women who were randomly allocated to either the EstroG\u2010100 group (<jats:italic>n<\/jats:italic>\u2009=\u200931) or the placebo group (<jats:italic>n<\/jats:italic>\u2009=\u200933). Primary end\u2010points were the mean change in scores of the Kupperman menopause index (KMI) that evaluates 11 symptoms, and the mean change in scores of vaginal dryness. The mean KMI score was significantly reduced in the EstroG\u2010100 group from 29.5\u2009\u00b1\u20097.4 at baseline to 11.3\u2009\u00b1\u20095.8 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) compared with change of the placebo group (29.2\u2009\u00b1\u20096.6 at baseline vs 23.7\u2009\u00b1\u20097.7 at week 12). The constituting symptoms of vasomotor, paresthesia, insomnia, nervousness, melancholia, vertigo, fatigue and rheumatic pain were significantly improved in the EstroG\u2010100 group in comparison with the placebo group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Statistically significant improvement in vaginal dryness in the EstroG\u2010100 group was also observed compared with that of the placebo group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In conclusion, EstroG\u2010100 significantly improved the menopausal symptoms of pre\u2010, peri\u2010 and post\u2010menopausal women without weight gain or any serious side effects. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3597","type":"journal-article","created":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T10:47:15Z","timestamp":1314960435000},"page":"510-516","source":"Crossref","is-referenced-by-count":59,"title":["The Effect of Herbal Extract (EstroG\u2010100) on Pre\u2010, Peri\u2010 and Post\u2010Menopausal Women: A Randomized Double\u2010blind, Placebo\u2010controlled Study"],"prefix":"10.1002","volume":"26","author":[{"given":"Albert","family":"Chang","sequence":"first","affiliation":[{"name":"Shady Canyon Medical Group  16300 Sand Canyon, Suite 909 Irvine CA 92618 USA"},{"name":"Friends Medical Group  2654 West La Palma Avenue Anaheim CA 92801 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u2010Yeon","family":"Kwak","sequence":"additional","affiliation":[{"name":"Herbal Hormone Research Institute Naturalendo Tech Co., Ltd  414 Daerung Post Tower 1, 212\u20108 Guro\u2010dong 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