{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:01:36Z","timestamp":1792004496090,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T00:00:00Z","timestamp":1317772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:italic>Huernia<\/jats:italic>species are typical famine\u2010food plants consumed in southern Ethiopia.<jats:italic>H. hystrix<\/jats:italic>is a heavily exploited ethnomedicinal succulent plant traded in traditional medicine systems especially on South Africa's eastern seaboard. This study investigated the acetylcholinesterase (AChE) inhibition, antioxidant, antiinflammatory and antimicrobial properties of extracts obtained from the stems and roots of this plant. At the same concentration level (625.0, 312.5 or 156.3\u2009\u00b5g\/mL), the whole plant extract showed higher AChE inhibitory activity when compared with the stem and root extracts; a finding suggesting the presence of AChE inhibitors acting additively or synergistically in the whole plant extract. The roots showed strong antioxidant activity (in DPPH and \u03b2\u2010carotene assays) comparable to that of butylated hydroxytoluene (BHT), indicating the presence of potent antioxidant compound(s) that can be exploited as alternatives for use in the food and cosmetic industries and\/or as nutraceuticals. All the petroleum ether (PE) (except root PE) and dichloromethane (DCM) extracts demonstrated good inhibitory activity (&gt; 70%) in cyclooxygenase (COX\u20101 and COX\u20102) assays at a 0.25\u2009\u00b5g\/\u03bcL concentration. Most of the extracts showed broad\u2010spectrum inhibitory and lethal activities against the microorganisms used in this study. The observed biological activities might be due to the iridoid, phenolic and flavonoid contents of the plants. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3614","type":"journal-article","created":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T17:18:03Z","timestamp":1317835083000},"page":"639-645","source":"Crossref","is-referenced-by-count":12,"title":["Acetylcholinesterase Inhibition, Antioxidant, Antiinflammatory, Antimicrobial and Phytochemical Properties of<i>Huernia hystrix<\/i>"],"prefix":"10.1002","volume":"26","author":[{"given":"Stephen O.","family":"Amoo","sequence":"first","affiliation":[{"name":"Research Centre for Plant Growth and Development School of Biological and Conservation Sciences University of KwaZulu\u2010Natal Pietermaritzburg Private Bag X01 Scottsville 3209 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey F.","family":"Finnie","sequence":"additional","affiliation":[{"name":"Research Centre for Plant Growth and Development School of Biological and Conservation Sciences University of KwaZulu\u2010Natal Pietermaritzburg Private Bag X01 Scottsville 3209 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Van Staden","sequence":"additional","affiliation":[{"name":"Research Centre for Plant Growth and Development School of Biological and Conservation Sciences University of KwaZulu\u2010Natal Pietermaritzburg Private Bag X01 Scottsville 3209 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(03)00278-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11240-008-9484-8"},{"key":"e_1_2_7_4_1","volume-title":"Medicinal and Magical Plants of Southern Africa: An Annotated Checklist","author":"Arnold TH","year":"2002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955708786369564"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/np9604893"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.57.765"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.55.689"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.08.049"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957563"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1078\/0944711041495218"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.11.015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.03.012"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.04.010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3746(74)90006-7"},{"key":"e_1_2_7_17_1","unstructured":"GuinandY LemessaD.2000.Wild\u2010food Plants in Southern Ethiopia: Reflections on the Role of \u2018Famine\u2010foods\u2019 at a Time of Drought. 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