{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:08:52Z","timestamp":1790845732399,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T00:00:00Z","timestamp":1321488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Banaba (<jats:italic>Lagerstroemia speciosa<\/jats:italic> L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This review summarizes the current literature regarding banaba and its constituents. The hypoglycemic effects of banaba have been attributed to both corosolic acid as well as ellagitannins. Studies have been conducted in various animal models, human subjects and <jats:italic>in vitro<\/jats:italic> systems using water soluble banaba leaf extracts, corosolic acid\u2010standardized extracts, and purified corosolic acid and ellagitannins. Pure corosolic acid has been reported to decrease blood sugar levels within 60\u2009min in human subjects. Corosolic acid also exhibits antihyperlipidemic, antioxidant, antiinflammatory, antifungal, antiviral, antineoplastic and osteoblastic activities. The beneficial effects of banaba and corosolic acid with respect to various aspects of glucose and lipid metabolism appear to involve multiple mechanisms, including enhanced cellular uptake of glucose, impaired hydrolysis of sucrose and starches, decreased gluconeogenesis and the regulation of lipid metabolism. These effects may be mediated by PPAR, MAP K, NF\u2010\u03baB and other signal transduction factors. No adverse effects have been observed or reported in animal studies or controlled human clinical trials. Banaba extract, corosolic acid and other constituents may be beneficial in addressing the symptoms associated with metabolic syndrome, as well as offering other health benefits. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3664","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T15:25:11Z","timestamp":1321543511000},"page":"317-324","source":"Crossref","is-referenced-by-count":114,"title":["A Review of the Efficacy and Safety of Banaba (<i>Lagerstroemia speciosa<\/i> L.) and Corosolic Acid"],"prefix":"10.1002","volume":"26","author":[{"given":"Sidney J.","family":"Stohs","sequence":"first","affiliation":[{"name":"Creighton University Medical Center  Omaha NE 68178 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Miller","sequence":"additional","affiliation":[{"name":"Nutratech Inc.  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