{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:31:23Z","timestamp":1760783483509,"version":"3.38.0"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T00:00:00Z","timestamp":1323907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>The present work was carried out to provide a pharmacological base for the medicinal use of<jats:italic>Andropogon muricatus<\/jats:italic>in airways disorders, such as asthma. In isolated guinea\u2010pig tracheal strips, the crude extract of<jats:italic>Andropogon muricatus<\/jats:italic>exhibited a non\u2010specific relaxant effect against carbachol (1\u2009\u00b5<jats:sc>m<\/jats:sc>) and high K<jats:sup>+<\/jats:sup>precontractions, with EC<jats:sub>50<\/jats:sub>values of 0.10 (0.07\u20130.11) and 0.15\u2009mg\/mL (0.11\u20130.18), respectively, similar to papaverine, while verapamil was more potent against high K<jats:sup>+<\/jats:sup>. This suggests the involvement of a non\u2010specific relaxant effect, mediated possibly through Ca<jats:sup>++<\/jats:sup>channel blockade and phosphodiesterase inhibition. The functional nature of the relaxant effect was further confirmed through indirect evidence when pretreatment of the tissues with the plant extract caused potentiation of the isoprenaline inhibitory response curves, similar to papaverine, while the effect of verapamil remained unchanged. These data indicate that the crude extract of<jats:italic>Andropogon muricatus<\/jats:italic>contains constituent(s) that mediate the tracheal relaxant effect, possibly through dual inhibition of Ca<jats:sup>++<\/jats:sup>channels and phosphodiesterase and provide pharmacological evidence for its medicinal use in airways disorders, particularly asthma. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3687","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T07:32:36Z","timestamp":1323934356000},"page":"1256-1258","source":"Crossref","is-referenced-by-count":10,"title":["The Calcium Channel Blocking and Phosphodiesterase Inhibitory Activities of the Extract of<i>Andropogon muricatus<\/i>Explains its Medicinal Use in Airways Disorders"],"prefix":"10.1002","volume":"26","author":[{"given":"Abdul Jabbar","family":"Shah","sequence":"first","affiliation":[{"name":"Natural Products Research Unit, Department of Biological and Biomedical Sciences Aga Khan University Medical College Karachi\u2010 74800 Pakistan"},{"name":"Department of Pharmacy COMSATS, Institute of Information Technology University Road Abbottabad\u2010 22060 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwarul Hassan","family":"Gilani","sequence":"additional","affiliation":[{"name":"Natural Products Research Unit, Department of Biological and Biomedical Sciences Aga Khan University Medical College Karachi\u2010 74800 Pakistan"},{"name":"King Saud University Ryad Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012178"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420040463"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y07-079"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0031-6997(25)06867-X","article-title":"Calcium antagonism and calcium entry blockade","volume":"38","author":"Godfraind T","year":"1986","journal-title":"Pharmacol Rev"},{"volume-title":"Medicinal Plants (Indigineous and Exotic) Used in Ceylon Part III","year":"1981","author":"Jayaweera DMA","key":"e_1_2_5_6_1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf050833e"},{"key":"e_1_2_5_8_1","first-page":"779","article-title":"Anti\u2010asthmatic properties of calcium antagonists","volume":"30","author":"Mathewson HS","year":"1985","journal-title":"Res Care"},{"volume-title":"Guide for the Care and Use of Laboratory Animals","year":"1996","author":"National Research Council","key":"e_1_2_5_9_1"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-837774"},{"volume-title":"Pharmacology","year":"1999","author":"Rang HP","key":"e_1_2_5_11_1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3263"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.07.024"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.3687","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.3687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T21:42:32Z","timestamp":1742074952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.3687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,15]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1002\/ptr.3687"],"URL":"https:\/\/doi.org\/10.1002\/ptr.3687","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"type":"print","value":"0951-418X"},{"type":"electronic","value":"1099-1573"}],"subject":[],"published":{"date-parts":[[2011,12,15]]}}}