{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:55:07Z","timestamp":1770537307605,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T00:00:00Z","timestamp":1324512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>Phytochemical study of <jats:italic>Gochnatia polymorpha<\/jats:italic> (Less) Cabr. ssp. <jats:italic>floccosa<\/jats:italic> Cabr. trunk bark, guided by antiproliferative assays on 10 human cancer cell lines and the VERO cell line, yielded six known compounds identified as the triterpene bauerenyl acetate, the guaianolide 11\u03b1,13\u2010dihydrozaluzanin C and the dimeric guaianolides 10\u2010desoxygochnatiolide A, gochnatiolide A, 8\u2010hydroxi\u201010\u2010desoxygochnatiolide A and 8\u2010hydroxigochnatiolide A. Extracts, fractions of extracts and isolated compounds were tested <jats:italic>in vitro<\/jats:italic> against a panel of human cancer cell lines, including U251 (glioma, CNS), UACC\u201062 (melanoma), MCF\u20107 (breast), NCI\u2010ADR\/RES (drug\u2010resistant ovarian), 786.0 (kidney), NCI\u2010H460 (lung, no small cells), PC\u20103 (prostate), OVCAR\u20103 (ovarian), HT\u201029 (colon), K562 (leukemia) and against the VERO no cancer cell line. Bauerenyl acetate was inactive, while 11\u03b1,13\u2010dihydrozaluzanin C showed weak activity against UACC62 and the VERO cell line. The most active compounds were 10\u2010desoxygochnatiolide A and gochnatiolide A, which inhibited the growth of kidney, melanoma, ovarian\u2010resistant and glioma cell lines with values of TGI (total growth inhibition) varying 0.21\u20131.09\u2009\u00b5g\/mL. This is the first report about cytotoxic activity of dimeric lactones against cell lines. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.3693","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T20:10:12Z","timestamp":1324584612000},"page":"1053-1056","source":"Crossref","is-referenced-by-count":17,"title":["Bioactivity\u2010guided Isolation of Cytotoxic Sesquiterpene Lactones of <i>Gochnatia polymorpha<\/i> ssp. <i>floccosa<\/i>"],"prefix":"10.1002","volume":"26","author":[{"given":"Regiane L. B.","family":"Strapasson","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica UFPR  C. P. 19081 81531\u2010990 Curitiba PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando C.","family":"Cervi","sequence":"additional","affiliation":[{"name":"Departamento de Bot\u00e2nica UFPR  C. P. 19041 81531\u2010990 Curitiba PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o E.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Farmacologia e Toxicologia CPQBA, UNICAMP  C. P. 6109 13083\u2010970 Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L\u00facia T. G.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Farmacologia e Toxicologia CPQBA, UNICAMP  C. P. 6109 13083\u2010970 Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos J.","family":"Salvador","sequence":"additional","affiliation":[{"name":"Curso de Farm\u00e1cia, Departamento de Biologia Vegetal, Instituto de Biologia UNICAMP  C. P. 6109 13083\u2010970 Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria \u00c9lida A.","family":"Stefanello","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica UFPR  C. 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